Microscopic changes induced by the intratracheal inoculation of amniotic fluid and meconium in the lung of neonatal rats

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:51Z
Fecha de publicación2002-01-01
ResumenMeconium aspiration syndrome is a major contributor to neonatal respiratory distress in infants and it has been sporadically recognized in neonatal animals. This investigation was designed to study the short and long term effects of meconium and amniotic fluid in the lungs of neonatal rats. Seven-day-old rats (n=123) divided in three groups were intratracheally inoculated with saline solution, amniotic fluid or meconium. Rats were euthanatized on 1, 3, 7, 14, 28, 56 and 112 postinoculation days (PID) and the lungs were examined by light microscopy. Saline solution did not induce any change while amniotic fluid elicited only a mild foreign body response which disappeared by PID 14. In contrast, meconium induced an exudative alveolitis characterized by recruitment of neutrophilsn in the bronchoalveolar spaces. Meconium also induced atelectasis, hyperinflation and thickening of alveolar septa all of which had disappeared by PID 14. Starting at PID 7, neutrophils were progressively replaced by macrophages, giant cells, and some fibroblasts. There were sporadic foci of mineralization starting at PID 14 and lasting up to PID 112. Some mineralized foci became lined with cuboidal epithelial cells at PID 28. Meconium was slowly degraded but still evident by PID 112. It was concluded that inoculation of meconium in neonatal rats induces acute microscopic changes typical of meconium aspiration syndrome. The long term lesions induced by meconium consisted of persistent multifocal histiocytic alveolitis and bronchiolitis reaction with occasional foci of calcification.es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4691
Idiomaenes_ES
EditorialF HERNANDEZes_ES
RelaciónHistology and Histopathologyes_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHistology and Histopathology
Palabra clavelunges_ES
Palabra claveneonatal ratses_ES
Palabra claveamniotic fluides_ES
Palabra clavemeconiumes_ES
Palabra claveaspirationes_ES
TítuloMicroscopic changes induced by the intratracheal inoculation of amniotic fluid and meconium in the lung of neonatal ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMartínez-Burnes, J
AutorLópez, A
AutorWright, GM
AutorIreland, WP
AutorWadowska, DW
AutorDobbin, GV
AutorMartínez-Burnes, Jes_ES
AutorLópez, Aes_ES
AutorWright, GMes_ES
AutorIreland, WPes_ES
AutorWadowska, DWes_ES
AutorDobbin, GVes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas1067-1076es_ES
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen17es_ES

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