Pituitary and adrenals are required for hyperglycemic reflex initiated by stimulation of CBR with cyanide

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:21Z
Fecha de publicación1997-01-01
ResumenWe have previously shown that stimulation of carotid body receptors (CBR) with sodium cyanide (NaCN) elicits a rapid hyperglycemic reflex. Here we explore whether the pituitary and adrenals, two glands involved in glucose homeostasis, are necessary for this reflex. Experiments were performed on anesthetized rats that were artificially ventilated. Measurements of hepatic venous-arterial glucose difference indicated that CBR stimulation with a bolus of 5 mu g/100 g NaCN produced an immediate increase in the output of glucose by the liver. The same dose of NaCN failed to increase hepatic output of glucose in rats with bilateral adrenalectomy or in rats 1 wk after surgical removal of neurohypophysis. Reflex glucose output by the liver was maintained after adenohypophysectomy or in adrenalectomized rats after adrenal autotransplantation to epiploon. Measurements of epinephrine in plasma and in the grafted adrenal tissue showed that the adrenal autograft can store and secrete catecholamines. Immunocytochemical observations indicated that the grafted adrenals retain medullary cells. These results indicate that neurohypophysis and adrenals are necessary for the hyperglycemic reflex initiated by CBR stimulation with NaCN and that the participation of these two organs in this reflex is probably humoral.es_ES
Doihttps://doi.org/10.1152/ajpregu.1997.272.1.r392es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5189
Idiomaenes_ES
EditorialAMER PHYSIOLOGICAL SOCes_ES
RelaciónAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiologyes_ES
URL relacionadohttps://doi.org/10.1152/ajpregu.1997.272.1.r392es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Palabra clavechemoreceptorses_ES
Palabra claveglucosees_ES
Palabra clavehypophysises_ES
Palabra claveneurohypophysises_ES
Palabra clavecatecholamineses_ES
Palabra claveliveres_ES
Palabra clavetyrosine hydroxylasees_ES
TítuloPituitary and adrenals are required for hyperglycemic reflex initiated by stimulation of CBR with cyanidees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAlvarezBuylla, R
AutorAlvarezBuylla, E
AutorMendoza, H
AutorMontero, SA
AutorAlvarezBuylla, A
AutorAlvarezBuylla, Res_ES
AutorAlvarezBuylla, Ees_ES
AutorMendoza, Hes_ES
AutorMontero, SAes_ES
AutorAlvarezBuylla, Aes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginasR392-R399es_ES
URL relacionadahttps://doi.org/10.1152/ajpregu.1997.272.1.r392
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen272es_ES

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