The association between the 844ins68 polymorphism in the CBS gene and breast cancer

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:48Z
Fecha de publicación2014-01-01
ResumenIntroduction: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer. Material and methods: We examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC). Results: The observed genotype frequencies for controls and BC patients were 1\% and 2\% for Ins/Ins, 13\% and 26\% for W/Ins, and 86\% and 72\% for W/W, respectively. We found that the odds ratio (OR) was 2.2, with a 95\% confidence interval (95\% Cl) of 1.5-3.3, p = 0.0001. The association was also evident when comparing the distribution of the W/Ins-Ins/Ins genotypes in patients in the following categories: 1) menopause and high gamma-glutamyltransferase (GGT) levels (OR of 2.17, 95\% Cl: 1.17-4.26, p = 0.02), 2) chemotherapy response and high lactate dehydrogenase (LDH) levels (OR 2.2, 95\% Cl: 1.08-4.4, p = 0.027), 3) chemotherapy response and high GGT levels (OR 2.46, 95\% Cl: 1.2-4.8, p = 0.007), and 4) body mass index (BMI) and III IV tumor stage (OR 3.2, 95\% Cl: 1.2-8.3, p = 0.013). Conclusions: We conclude that the genotypes W/Ins-I ns/Ins of the 844ins68 polymorphism in the CBS gene contribute significantly to BC susceptibility in the analyzed sample from the Mexican population.es_ES
Doihttps://doi.org/10.5114/aoms.2014.47830es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4618
Idiomaenes_ES
EditorialTERMEDIA PUBLISHING HOUSE LTDes_ES
RelaciónArchives of Medical Sciencees_ES
URL relacionadohttps://doi.org/10.5114/aoms.2014.47830es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteArchives of Medical Science
Palabra clave844ins68es_ES
Palabra claveT833Ces_ES
Palabra clavepolymorphismes_ES
Palabra clavebreast canceres_ES
Palabra claveMexican populationes_ES
TítuloThe association between the 844ins68 polymorphism in the CBS gene and breast canceres_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPatricia Gallegos-Arreola, Martha
AutorEduardo Figuera-Villanueva, Luis
AutorRamos-Silva, Adriana
AutorSalas-Gonzalez, Efrain
AutorMaria Puebla-Perez, Ana
AutorPeralta-Leal, Valeria
AutorElias Garcia-Ortiz, Jose
AutorPatricia Davalos-Rodriguez, Ingrid
AutorMoises Zuniga-Gonzalez, Guillermo
AutorPatricia Gallegos-Arreola, Marthaes_ES
AutorEduardo Figuera-Villanueva, Luises_ES
AutorRamos-Silva, Adrianaes_ES
AutorSalas-Gonzalez, Efraines_ES
AutorMaria Puebla-Perez, Anaes_ES
AutorPeralta-Leal, Valeriaes_ES
AutorElias Garcia-Ortiz, Josees_ES
AutorPatricia Davalos-Rodriguez, Ingrides_ES
AutorMoises Zuniga-Gonzalez, Guillermoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número6es_ES
Rango de páginas1214-1224es_ES
URL relacionadahttps://doi.org/10.5114/aoms.2014.47830
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

Files

Collections

Documentación Cientifica