Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:41Z
Fecha de publicación2019-01-01
ResumenRheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications of inflammation. Cartilage antibody-induced pain-like behavior does not depend on complement activation or joint inflammation, but instead on tissue antigen recognition and local immune complex (IC) formation. smFISH and IHC suggest that neuronal Fcgr1 and Fcgr2b mRNA are transported to peripheral ends of primary afferents. CII-ICs directly activate cultured WT but not FcR gamma chain-deficient DRG neurons. In line with this observation, CII-IC does not induce mechanical hypersensitivity in FcR gamma chain-deficient mice. Furthermore, injection of CII antibodies does not generate pain-like behavior in FcR gamma chain-deficient mice or mice lacking activating Fc gamma Rs in neurons. In summary, this study defines functional coupling between autoantibodies and pain transmission that may facilitate the development of new disease-relevant pain therapeutics.es_ES
Doihttps://doi.org/10.1084/jem.20181657es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5494
Idiomaenes_ES
EditorialROCKEFELLER UNIV PRESSes_ES
RelaciónJournal of Experimental Medicinees_ES
URL relacionadohttps://doi.org/10.1084/jem.20181657es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Experimental Medicine
TítuloCartilage-binding antibodies induce pain through immune complex-mediated activation of neuronses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorFarinotti, Alex Bersellini
AutorWigerblad, Gustaf
AutorNascimento, Diana
AutorBas, Duygu B.
AutorUrbina, Carlos Morado
AutorNandakumar, Kutty Selva
AutorSandor, Katalin
AutorXu, Bingze
AutorAbdelmoaty, Sally
AutorHunt, Matthew A.
AutorMoller, Kristina Angeby
AutorBaharpoor, Azar
AutorSinclair, Jon
AutorJardemark, Kent
AutorLanner, Johanna T.
AutorKhmaladze, Ia
AutorBorm, Lars E.
AutorZhang, Lu
AutorWermeling, Fredrik
AutorCragg, Mark S.
AutorLengqvist, Johan
AutorChabot-Dore, Anne-Julie
AutorDiatchenko, Luda
AutorBelfer, Inna
AutorCollin, Mattias
AutorKultima, Kim
AutorHeyman, Birgitta
AutorMiguel Jimenez-Andrade, Juan
AutorCodeluppi, Simone
AutorHolmdahl, Rikard
AutorSvensson, Camilla I.
AutorFarinotti, Alex Bersellinies_ES
AutorWigerblad, Gustafes_ES
AutorNascimento, Dianaes_ES
AutorBas, Duygu B.es_ES
AutorUrbina, Carlos Moradoes_ES
AutorNandakumar, Kutty Selvaes_ES
AutorSandor, Katalines_ES
AutorXu, Bingzees_ES
AutorAbdelmoaty, Sallyes_ES
AutorHunt, Matthew A.es_ES
AutorMoller, Kristina Angebyes_ES
AutorBaharpoor, Azares_ES
AutorSinclair, Jones_ES
AutorJardemark, Kentes_ES
AutorLanner, Johanna T.es_ES
AutorKhmaladze, Iaes_ES
AutorBorm, Lars E.es_ES
AutorZhang, Lues_ES
AutorWermeling, Fredrikes_ES
AutorCragg, Mark S.es_ES
AutorLengqvist, Johanes_ES
AutorChabot-Dore, Anne-Juliees_ES
AutorDiatchenko, Ludaes_ES
AutorBelfer, Innaes_ES
AutorCollin, Mattiases_ES
AutorKultima, Kimes_ES
AutorHeyman, Birgittaes_ES
AutorMiguel Jimenez-Andrade, Juanes_ES
AutorCodeluppi, Simonees_ES
AutorHolmdahl, Rikardes_ES
AutorSvensson, Camilla I.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
Rango de páginas1904-1924es_ES
URL relacionadahttps://doi.org/10.1084/jem.20181657
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen216es_ES

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