The role of cannabinoids in pain modulation in companion animals

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:25Z
Fecha de publicación2023-01-01
ResumenThe use of cannabinoids in both veterinary and human medicine is controversial for legal and ethical reasons. Nonetheless, the availability and therapeutic use of naturally occurring or synthetic phytocannabinoids, such as Delta(9)-tetrahydrocannabidiol and cannabidiol, have been the focus of attention in studies regarding their medical uses. This review aims to examine the role of cannabinoids in pain modulation by analyzing scientific findings regarding the signaling pathways of the endocannabinoid system and discussing the analgesic effects of synthetic cannabinoids compared to cannabinoid extracts and the extent and involvement of their receptors. In animals, studies have shown the analgesic properties of these substances and the role of the cannabinoid binding -1 (CB1) and cannabinoid binding -2 (CB2) receptors in the endocannabinoid system to modulate acute, chronic and neuropathic pain. This system consists of three main components: endogenous ligands (anandamide and 2-arachidonoylglycerol), G protein-coupled receptors and enzymes that degrade and recycle the ligands. Evidence suggests that their interaction with CB1 receptors inhibits signaling in pain pathways and causes psychoactive effects. On the other hand, CB2 receptors are associated with anti-inflammatory and analgesic reactions and effects on the immune system. Cannabis extracts and their synthetic derivatives are an effective therapeutic tool that contributes to compassionate pain care and participates in its multimodal management. However, the endocannabinoid system interacts with different endogenous ligands and neurotransmitters, thus offering other therapeutic possibilities in dogs and cats, such is the case of those patients who suffer from seizures or epilepsy, contact and atopic dermatitis, degenerative myelopathies, asthma, diabetes and glaucoma, among other inflammatory diseases. Moreover, these compounds have been shown to possess antineoplastic, appetite-stimulating, and antiemetic properties. Ultimately, the study of the endocannabinoid system, its ligands, receptors, mechanism of action, and signaling, has contributed to the development of research that shows that hemp-derived and their synthetic derivatives are an effective therapeutic alternative in the multimodal management of pain in dogs and cats due to their ability to prevent peripheral and central sensitization.es_ES
Doihttps://doi.org/10.3389/fvets.2022.1050884es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5247
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Veterinary Sciencees_ES
URL relacionadohttps://doi.org/10.3389/fvets.2022.1050884es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Veterinary Science
Palabra claveanalgesiaes_ES
Palabra claveanimal welfarees_ES
Palabra clavecannabinoid receptorses_ES
Palabra claveendocannabinoid systemes_ES
Palabra clavemarijuanaes_ES
TítuloThe role of cannabinoids in pain modulation in companion animalses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMiranda-Cortes, Agatha
AutorMota-Rojas, Daniel
AutorCrosignani-Outeda, Nadia
AutorCasas-Alvarado, Alejandro
AutorMartinez-Burnes, Julio
AutorOlmos-Hernandez, Adriana
AutorMora-Medina, Patricia
AutorVerduzco-Mendoza, Antonio
AutorHernandez-Avalos, Ismael
AutorMiranda-Cortes, Agathaes_ES
AutorMota-Rojas, Danieles_ES
AutorCrosignani-Outeda, Nadiaes_ES
AutorCasas-Alvarado, Alejandroes_ES
AutorMartinez-Burnes, Julioes_ES
AutorOlmos-Hernandez, Adrianaes_ES
AutorMora-Medina, Patriciaes_ES
AutorVerduzco-Mendoza, Antonioes_ES
AutorHernandez-Avalos, Ismaeles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fvets.2022.1050884
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

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