Repeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund's adjuvant-induced knee arthritis

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:13Z
Fecha de publicación2017-01-01
ResumenBackground: The role of dopaminergic system in the development of rheumatoid arthritisrelated pain, a major symptom in this disease, has not been explored. Therefore, the antinociceptive effect of mazindol, a dopamine uptake inhibitor, was evaluated in a model of complete Freund's adjuvant (CFA)-induced arthritis. Furthermore, as studies have shown that the dopaminergic system regulates bone metabolism, the effect of mazindol on bone mass and microarchitecture was determined. Methods: Adult ICR male mice received intra-articular injections of either CFA or saline into the right knee joint every week. Spontaneous pain-like behaviors (flinching and guarding) and locomotor activity were assessed at day 26 post-first CFA, following which, a single intraperitoneally (i. p.) administered dose of mazindol was given (1, 3 and 10 mg/kg). Then, the antinociceptive effect of a repeated administration of 3 mg/kg mazindol (daily, i. p.; day 15-day 26) was evaluated. Additionally, at day 26, the participation of D1-like, D2-like or opioid receptors in the antinociceptive effect of mazindol was evaluated. The effect of mazindol on bone density and microarchitecture was evaluated by micro-computed tomography. Results: Acute administration of mazindol decreased the spontaneous pain-like behaviors in a dose-dependent manner without reducing the knee edema. However, mazindol at 10 mg/kg significantly increased the locomotor activity; therefore, 3 mg/kg mazindol was used for further studies. Repeated administration of 3 mg/kg mazindol significantly decreased the pain-like behaviors without modifying locomotor activity. The antinociceptive effect of mazindol was blocked by administration of a D2-like receptor antagonist (haloperidol), but not by administration of D1-like receptor antagonist (SCH 23390) or an opioid receptor antagonist (naloxone). Repeated administration of mazindol did not significantly modify the density and microarchitecture of periarticular bone of the arthritic and nonarthritic knee joints. Conclusion: Results suggest that mazindol via D2-like receptors has an antinociceptive role in mice with CFA-induced knee arthritis without modifying the bone health negatively.es_ES
Doihttps://doi.org/10.2147/jpr.s136581es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5045
Idiomaenes_ES
EditorialDOVE MEDICAL PRESS LTDes_ES
RelaciónJournal of Pain Researches_ES
URL relacionadohttps://doi.org/10.2147/jpr.s136581es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteJournal of Pain Research
Palabra clavedopaminees_ES
Palabra claveanalgesiaes_ES
Palabra clavearthritic paines_ES
Palabra clavemicro-computed tomographyes_ES
TítuloRepeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund's adjuvant-induced knee arthritises_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRobledo-Gonzalez, L. E.
AutorMartinez-Martinez, A.
AutorVargas-Munoz, V. M.
AutorAcosta-Gonzalez, R. I.
AutorPlancarte-Sanchez, R.
AutorAnaya-Reyes, M.
AutorFernandez del Valle-Laisequilla, C.
AutorReyes-Garcia, J. G.
AutorJimenez-Andrade, J. M.
AutorRobledo-Gonzalez, L. E.es_ES
AutorMartinez-Martinez, A.es_ES
AutorVargas-Munoz, V. M.es_ES
AutorAcosta-Gonzalez, R. I.es_ES
AutorPlancarte-Sanchez, R.es_ES
AutorAnaya-Reyes, M.es_ES
AutorFernandez del Valle-Laisequilla, C.es_ES
AutorReyes-Garcia, J. G.es_ES
AutorJimenez-Andrade, J. M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Rango de páginas1777-1786es_ES
URL relacionadahttps://doi.org/10.2147/jpr.s136581
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

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