Quinoxaline 1,4-di-N-oxide Derivatives as New Antinocardial Agents

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:14Z
Fecha de publicación2024-01-01
ResumenMycetoma is currently considered as a neglected tropical disease. The incidence of mycetoma is unknown but most of the worldwide cases are present in the “mycetoma belt” including countries like Mexico, India, Senegal, and others. The treatment of mycetoma depends on the etiological agent responsible for the case. Treatment success reaches 60 to 90%; however, common treatment has been reported to be ineffective in some cases, due in part to resistance to the prescribed antibiotics. Therefore, it is necessary to develop new therapeutic options. In the past two decades, quinoxaline derivatives have shown relevance as antibacterial agents. Therefore, in this work, esters of quinoxaline 1,4-di-N-oxide derivatives were evaluated in vitro against the reference strain CECT-3052 from N. brasiliensis, six clinical isolates, and macrophages J774A.1 to determine their cytotoxicity and security index. Additionally, nine reference drugs were evaluated as controls. The results show that nine esters of quinoxaline 1,4-di-N-oxide derivatives had a minimum inhibitory concentration (MIC) < 1 µg/mL against the reference strain and four of them (N-05, N-09, N-11, and N-13) had an MIC < 1 µg/mL against the clinical isolates. Therefore, the scaffold quinoxaline 1,4-di-N-oxide could be used to develop new and more potent antinocardial agents.es_ES
Doihttps://doi.org/10.3390/molecules29194652es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2174
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónMoleculeses_ES
URL relacionadohttps://doi.org/10.3390/molecules29194652es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMolecules
TítuloQuinoxaline 1,4-di-N-oxide Derivatives as New Antinocardial Agentses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPalos, Isidro
AutorGonzález-González, Alonzo
AutorPaz-González, Alma D.
AutorEspinoza-Hicks, José C.
AutorBandyopadhyay, Debasish
AutorPaniagua-Castro, Norma
AutorGaleana-Salazar, Marlene S.
AutorCastañeda-Sánchez, Jorge Ismael
AutorLuna-Herrera, Julieta
AutorRivera, Gildardo
AutorPalos, Isidroes_ES
AutorGonzález-González, Alonzoes_ES
AutorPaz-González, Alma D.es_ES
AutorEspinoza-Hicks, José C.es_ES
AutorBandyopadhyay, Debasishes_ES
AutorPaniagua-Castro, Normaes_ES
AutorGaleana-Salazar, Marlene S.es_ES
AutorCastañeda-Sánchez, Jorge Ismaeles_ES
AutorLuna-Herrera, Julietaes_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número19es_ES
Rango de páginas4652es_ES
URL relacionadahttps://doi.org/10.3390/molecules29194652
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen29es_ES

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