GABA receptor agonists in the medial preoptic area and maternal behavior in lactating rats

Simple item page
AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:25Z
Fecha de publicación2006-01-01
ResumenWe studied the effects of injecting agonists of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) muscimol (GABA-A receptor agonist) and baclofen (GABA-B receptor agonist) in the medial preoptic area (MPOA) and neighboring brain regions, the bed nucleus of the stria terminalis (BNST), and lateral preoptic area (LPO) on maternal behavior. Lactating female rats were implanted with bilateral carmulae in the MPOA/BNST on day 1 postpartum. On day 5, a maternal behavior test was conducted in the home cage after females received injections of muscimol or baclofen (0, 12.5, 50 or 200 ng per side). On day 7, after MPOA/BNST injections, a second maternal behavior test was conducted with pups placed at the end of a T-runway projecting from the home cage. Finally, after injections on day 9 maternal aggression, olfaction, and locomotor behavior were tested. The GABA receptor agonists injected in the MPOA/BNST produced dose-dependent deficits in all components of maternal behavior, including maternal aggression, except licking. Muscimol produced deficits in the active component, nest building at lower doses than baclofen, both agonists produced deficits in retrieving, while baclofen produced deficits in passive components (hovering and crouching over pups) at lower doses than muscimol. Both GABA receptor agonists increased locomotor activity and reduced olfactory responsiveness but these were only correlated with deficits in retrieving and crouching in baclofen-treated females. (c) 2005 Elsevier Inc. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.physbeh.2005.08.048es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5252
Idiomaenes_ES
EditorialPERGAMON-ELSEVIER SCIENCE LTDes_ES
RelaciónPhysiology \& Behaviores_ES
URL relacionadohttps://doi.org/10.1016/j.physbeh.2005.08.048es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuentePhysiology \& Behavior
Palabra clavemuscimoles_ES
Palabra clavebaclofenes_ES
Palabra claveGABAes_ES
Palabra clavematernal behaviores_ES
Palabra clavemedial preoptic areaes_ES
TítuloGABA receptor agonists in the medial preoptic area and maternal behavior in lactating ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorArrati, PG
AutorCarmona, C
AutorDominguez, G
AutorBeyer, C
AutorRosenblatt, JS
AutorArrati, PGes_ES
AutorCarmona, Ces_ES
AutorDominguez, Ges_ES
AutorBeyer, Ces_ES
AutorRosenblatt, JSes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas51-65es_ES
URL relacionadahttps://doi.org/10.1016/j.physbeh.2005.08.048
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen87es_ES

Files

Collections

Documentación Cientifica