Arthroscopic Matrix-Encapsulated Autologous Chondrocyte Implantation: A Pilot Multicenter Investigation in Latin America

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:08Z
Fecha de publicación2021-01-01
ResumenObjective. To evaluate minimum biosecurity parameters (MBP) for arthroscopic matrix-encapsulated autologous chondrocyte implantation (AMECI) based on patients' clinical outcomes, magnetic resonance imaging (MRI) T2-mapping, Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, and International Cartilage Repair Society (ICRS) second-look arthroscopic evaluation, laying the basis for a future multicenter study. Design. Pilot clinical study. We analyzed the logistics to perform AMECI to treat focal chondral lesions in different hospitals following strict biosecurity parameters related to tissue and construct transportation, chondrocyte isolation, and cell expansion. Patient progress was analyzed with patient-reported outcome measures, MRI T2-mapping, MOCART, and ICRS arthroscopic second-look evaluation. Results. Thirty-five lesions in 30 patients treated in 7 different hospitals were evaluated. Cell viability before implantation was >90\%. Cell viability in construct remnants was 87\% +/- 11\% at 24 hours, 75\% +/- 17.1\% at 48 hours, and 60\% +/- 8\% at 72 hours after implantation. Mean final follow-up was 37 months (12-72 months). Patients showed statistically significant improvement in all clinical scores and MOCART evaluations. MRI T2-mapping evaluation showed significant decrease in relaxation time from 61.2 +/- 14.3 to 42.9 +/- 7.2 ms (P < 0.05). Arthroscopic second-look evaluation showed grade II ``near normal{''} tissue in 83\% of patients. Two treatment failures were documented. Conclusions. It was feasible to perform AMECI in 7 different institutions in a large metropolitan area following our biosecurity measures without any implant-related complication. Treated patients showed improvement in clinical, MRI T2-mapping, and MOCART scores, as well as a low failure rate and a favorable ICRS arthroscopic evaluation at a mid-term follow-up. Level of Evidence. 2b.es_ES
Doihttps://doi.org/10.1177/1947603520918630es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4984
Idiomaenes_ES
EditorialSAGE PUBLICATIONS INCes_ES
RelaciónCartilagees_ES
URL relacionadohttps://doi.org/10.1177/1947603520918630es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCartilage
Palabra clavematrix-assisted autologous chondrocyte implantationes_ES
Palabra claveT2-mappinges_ES
Palabra clavebiosecurity parameterses_ES
Palabra claveAMECIes_ES
Palabra clavemulticenter studyes_ES
TítuloArthroscopic Matrix-Encapsulated Autologous Chondrocyte Implantation: A Pilot Multicenter Investigation in Latin Americaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorVillalobos, Enrique
AutorMadrazo-Ibarra, Antonio
AutorMartinez, Valentin
AutorOlivos-Meza, Anell
AutorVelasquillo, Cristina
AutorCortes Gonzalez, Socorro
AutorIzaguirre, Aldo
AutorOrtega-Sanchez, Carmina
AutorGonzalez, Ricardo
AutorParra-Cid, Carmen
AutorPerez-Jimenez, Francisco Javier
AutorIbarra, Clemente
AutorVillalobos, Enriquees_ES
AutorMadrazo-Ibarra, Antonioes_ES
AutorMartinez, Valentines_ES
AutorOlivos-Meza, Anelles_ES
AutorVelasquillo, Cristinaes_ES
AutorCortes Gonzalez, Socorroes_ES
AutorIzaguirre, Aldoes_ES
AutorOrtega-Sanchez, Carminaes_ES
AutorGonzalez, Ricardoes_ES
AutorParra-Cid, Carmenes_ES
AutorPerez-Jimenez, Francisco Javieres_ES
AutorIbarra, Clementees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1\_SUPPL, 1\_, SIes_ES
Rango de páginas1074S-1084Ses_ES
URL relacionadahttps://doi.org/10.1177/1947603520918630
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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