New Tool Against Tuberculosis: The Potential of the LAMP Lateral Flow Assay in Resource-Limited Settings

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:09Z
Fecha de publicación2025-01-01
ResumenTuberculosis (TB) is a global public health issue requiring early and accurate diagnosis. The loop-mediated isothermal amplification (LAMP) assay is a promising alternative recommended by the WHO for the initial diagnosis of pulmonary TB, particularly in resource-limited settings. This study evaluated the sensitivity and specificity of a commercial LAMP assay for TB detection using 198 samples from different countries including Mexico. The LAMP assay results were compared to the results of standard tests: AFB smear microscopy, cell culture, and Xpert PCR. Across all samples, LAMP showed a sensitivity of 96.20% and a specificity of 84.61%. When compared specifically to “true positives” and “true negatives” (defined by the consistency across the standard tests), LAMP demonstrated 100% sensitivity and 92.30% specificity. For context, the sensitivity of AFB smear microscopy against the culture and Xpert tests was 79.04%. A significant finding was that the LAMP test detected a high percentage (92.5%) of samples found positive by the culture and Xpert tests but negative by the AFB smear, highlighting its ability to identify cases missed by traditional microscopy. This study concluded that the LAMP assay is a sensitive and specific tool for TB diagnosis with potential for rapid and accurate diagnosis, especially in resource-limited areas.es_ES
Doihttps://doi.org/10.3390/cimb47080585es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2102
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónCurrent Issues in Molecular Biologyes_ES
URL relacionadohttps://doi.org/10.3390/cimb47080585es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCurrent Issues in Molecular Biology
TítuloNew Tool Against Tuberculosis: The Potential of the LAMP Lateral Flow Assay in Resource-Limited Settingses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRosas-Diaz, Marisol
AutorPalacios-Reyes, Carmen
AutorGodinez-Aguilar, Ricardo
AutorEscalante-Bautista, Deyanira
AutorHernández, Laura Alfaro
AutorJuarez-Islas, Ana P.
AutorSegundo-Ibañez, Patricia
AutorSalas-Cuevas, Gabriela
AutorOlvera-Serrano, Ángel
AutorHernandez-Martinez, Juan Carlos
AutorRamos-Garcia, Victor Hugo
AutorOropesa, Esperanza Milagros Garcia
AutorFlores-García, Omar
AutorGalvez-Romero, Jose Luis
AutorBurgoa, Griselda León
AutorNolasco-Quiroga, Manuel
AutorRosas-Diaz, Marisoles_ES
AutorPalacios-Reyes, Carmenes_ES
AutorGodinez-Aguilar, Ricardoes_ES
AutorEscalante-Bautista, Deyaniraes_ES
AutorHernández, Laura Alfaroes_ES
AutorJuarez-Islas, Ana P.es_ES
AutorSegundo-Ibañez, Patriciaes_ES
AutorSalas-Cuevas, Gabrielaes_ES
AutorOlvera-Serrano, Ángeles_ES
AutorHernandez-Martinez, Juan Carloses_ES
AutorRamos-Garcia, Victor Hugoes_ES
AutorOropesa, Esperanza Milagros Garciaes_ES
AutorFlores-García, Omares_ES
AutorGalvez-Romero, Jose Luises_ES
AutorBurgoa, Griselda Leónes_ES
AutorNolasco-Quiroga, Manueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
Rango de páginas585es_ES
URL relacionadahttps://doi.org/10.3390/cimb47080585
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen47es_ES

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