Relevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver disease

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:26Z
Fecha de publicación2025-01-01
ResumenIntroduction Grafts with alcohol-associated liver disease (ALD) subjected to prolonged cold ischaemia from donors after brain death (DBD) are typically unsuitable for transplantation. Here, we investigated the role of growth hormone (GH) in livers with ALD from DBDs and its relationship with vascular endothelial growth factor A (VEGFA) and VEGFB.Methods Livers from rats fed ethanol for 6 weeks and with brain death (BD) were cold stored for 24 h and subjected to ex vivo reperfusion. Hepatic damage and proliferative and inflammatory parameters were analysed after BD, before graft retrieval, and after reperfusion. Survival was monitored using an in vivo transplantation model.Results In DBDs, the administration of GH, which increased the levels in the intestine but not in the liver, induced the generation of both VEGFA and VEGFB in the intestine and protected against hepatic damage caused by BD before retrieving liver grafts from donors. However, VEGFA was the only factor that protected against damage after cold ischemia and reperfusion, which also increased the survival of the recipients.Discussion In conclusion, the signalling pathway and beneficial properties of the GH-VEGFA/VEGFB pathway, in which the intestine-liver axis plays a key role, were disrupted when grafts with ALD from DBDs were retrieved from donors and subjected to cold ischemia and reperfusion.es_ES
Doihttps://doi.org/10.3389/fcell.2024.1455258es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5278
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Cell and Developmental Biologyes_ES
URL relacionadohttps://doi.org/10.3389/fcell.2024.1455258es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Cell and Developmental Biology
Palabra claveliver transplantationes_ES
Palabra clavebrain deathes_ES
Palabra claveALDes_ES
Palabra claveischemia-reperfusiones_ES
Palabra clavegrowth hormonees_ES
Palabra claveVEGFes_ES
TítuloRelevance of the GH-VEGFB/VEGFA axis in liver grafts from brain-dead donors with alcohol-associated liver diseasees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMico-Carnero, Marc
AutorRojano-Alfonso, Carlos
AutorMaroto-Serrat, Cristina
AutorCutrin, Juan Carlos
AutorCasillas-Ramirez, Arani
AutorPeralta, Carmen
AutorMico-Carnero, Marces_ES
AutorRojano-Alfonso, Carloses_ES
AutorMaroto-Serrat, Cristinaes_ES
AutorCutrin, Juan Carloses_ES
AutorCasillas-Ramirez, Aranies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fcell.2024.1455258
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen12es_ES

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