Development of Chitosan–Hydroxyapatite Membranes from Bone of Armoured Catfish (Pterygoplichthys spp.) for Applications in Guided Bone Regeneration (GBR)

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:29:43Z
Fecha de publicación2025-01-01
ResumenNowadays, there is an increasing interest in the development of novel bioresorbable membranes for Guided Bone Regeneration (GBR), and for this purpose, hydroxyapatite, from different sources, has been tested in combination with chitosan. This work details the production and the characterization of membranes of chitosan reinforced with hydroxyapatite derived from the bone of armoured catfish (Pterygoplichthys spp.), which is a widely available natural resource. The hydroxyapatite was characterized morphologically and chemically after the particles of hydroxyapatite were incorporated into a chitosan matrix. Then, the impact of adding hydroxyapatite particles into a matrix of chitosan on the roughness, mechanical properties, degradation, and cytotoxicity was evaluated. Subsequently, an in vivo test was carried out with the purpose of elucidating its guided bone regeneration activity, where the newly developed chitosan–hydroxyapatite membranes were implanted in rabbits with calvarial bone defects. The membranes of chitosan–hydroxyapatite presented a very rough surface morphology compared to the membranes of chitosan; moreover, the membranes of chitosan–hydroxyapatite showed superior mechanical tensile properties. The Masson’s trichrome staining analysis histologically demonstrated that the membranes of chitosan–hydroxyapatite enhanced the formation of a complete mineralized bone matrix in the calvarial bone defects. Finally, these findings confirm that the bone of armoured catfish (Pterygoplichthys spp.) is a viable, economic, and environmentally friendly source for isolating hydroxyapatite, which, combined with a matrix of chitosan, can be a suitable alternative to develop biocompatible GBR membranes.es_ES
Doihttps://doi.org/10.3390/pr13051559es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/1716
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónProcesseses_ES
URL relacionadohttps://doi.org/10.3390/pr13051559es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteProcesses
TítuloDevelopment of Chitosan–Hydroxyapatite Membranes from Bone of Armoured Catfish (Pterygoplichthys spp.) for Applications in Guided Bone Regeneration (GBR)es_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLópez, Ricardo de Jesús Figueroa
AutorLuna-Domínguez, Carlos Roberto
AutorMendoza-Martínez, Ana María
AutorŞahin, Muradiye
AutorAl-Anzi, Bader Shafaqa
AutorCozza, Ronaldo Câmara
AutorLuna-Domínguez, Jorge Humberto
AutorLópez, Ricardo de Jesús Figueroaes_ES
AutorLuna-Domínguez, Carlos Robertoes_ES
AutorMendoza-Martínez, Ana Maríaes_ES
AutorŞahin, Muradiyees_ES
AutorAl-Anzi, Bader Shafaqaes_ES
AutorCozza, Ronaldo Câmaraes_ES
AutorLuna-Domínguez, Jorge Humbertoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
Rango de páginas1559es_ES
URL relacionadahttps://doi.org/10.3390/pr13051559
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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