Strategic interventions in clinical randomized trials for metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity in the pediatric population: a systematic review with meta-analysis and bibliometric analysis

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:40Z
Fecha de publicación2024-01-01
ResumenBackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a prevalent hepatic condition linked to metabolic alterations. It gradually causes liver damage and potentially progresses to cirrhosis. Despite its significance, research, especially in the pediatric population, is limited, leading to contradictory findings in diagnosis and treatment. This meta-analysis aims to synthesize existing literature on therapeutic interventions for MASLD in children and adolescents.MethodsA comprehensive search of randomized controlled clinical trials yielded 634 entries from PubMed, Scopus, and Web of Science up to 2023. Interventions included medications, behavioral modifications, dietary changes, probiotics, supplements, surgical procedures, or combinations. The analysis focused on studies with treatment duration of at least 3 months, employing a random-effects REML meta-analysis model. Treatment effects on anthropometric measurements and biochemical components were examined and adjusted for heterogeneity factors analysis. A bibliometric analysis for insights into research contributors was performed.ResultsThe systematic review incorporated 31 clinical trials, with 24 meeting criteria for meta-analysis. These comprised 3 medication studies, 20 with supplements, 4 focusing on lifestyle, and 4 centered on diets. Significant overall treatment effects were observed for ALT, AST, BMI, and HOMA-IR mainly by supplements and lifestyle. Meta-regression identified age, BMI changes, and treatment duration as factors modifying ALT concentrations. Bibliometric analysis involving 31 linked studies highlighted contributions from 13 countries, with the USA, Spain, and Chile being the most influential.ConclusionsWe conclude that supplementation and lifestyle changes can effectively impact ALT and AST levels, which can help address liver issues in obese children. However, the evaluation of risk bias, the high heterogeneity, and the bibliometric analysis emphasize the need for more high-quality studies and broader inclusion of diverse child populations to provide better therapeutic recommendations.Trial registrationPROSPERO, CRD42023393952. Registered on January 25, 2023.es_ES
Doihttps://doi.org/10.1186/s12916-024-03744-xes_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5480
Idiomaenes_ES
EditorialBMCes_ES
RelaciónBMC Medicinees_ES
URL relacionadohttps://doi.org/10.1186/s12916-024-03744-xes_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBMC Medicine
Palabra claveMASLD (metabolic dysfunction-associated steatotic liver disease)es_ES
Palabra clavePediatric NAFLDes_ES
Palabra claveTherapeutic interventionses_ES
Palabra claveRandomized controlled trialses_ES
Palabra claveMeta-analysises_ES
Palabra claveLiver enzymeses_ES
TítuloStrategic interventions in clinical randomized trials for metabolic dysfunction-associated steatotic liver disease (MASLD) and obesity in the pediatric population: a systematic review with meta-analysis and bibliometric analysises_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorOmana-Guzman, Isabel
AutorRosas-Diaz, Marisol
AutorMartinez-Lopez, Yoscelina Estrella
AutorPerez-Navarro, L. Monserrat
AutorDiaz-Badillo, Alvaro
AutorAlanis, Anthony
AutorBustamante, Alejandra
AutorCastillo-Ruiz, Octelina
Autordel Toro-Cisneros, Noemi
AutorEsquivel-Hernandez, Diego Armando
AutorGarcia-Villalobos, Gloria
AutorGaribay-Nieto, Nayely
AutorGarcia-Oropesa, Esperanza Milagros
AutorHernandez-Martinez, Juan Carlos
AutorLopez-Sosa, Elena Beatriz
AutorMaldonado, Carlos
AutorMartinez, David
AutorMembreno, Joshua
AutorMoctezuma-Chavez, Oscar Omar
AutorMunguia-Cisneros, Claudia X.
AutorNava-Gonzalez, Edna J.
AutorPerales-Torres, Adriana L.
AutorPerez-Garcia, Adolfo
AutorRivera-Marrero, Hector
AutorValdez, Alisha
AutorVazquez-Chavez, Alfonso Alejandro
AutorRamirez-Pfeiffer, Carlos
AutorCarter, Kathleen V.
AutorTapia, Beatriz
AutorVela, Leonel
AutorLopez-Alvarenga, Juan Carlos
AutorOmana-Guzman, Isabeles_ES
AutorRosas-Diaz, Marisoles_ES
AutorMartinez-Lopez, Yoscelina Estrellaes_ES
AutorPerez-Navarro, L. Monserrates_ES
AutorDiaz-Badillo, Alvaroes_ES
AutorAlanis, Anthonyes_ES
AutorBustamante, Alejandraes_ES
AutorCastillo-Ruiz, Octelinaes_ES
Autordel Toro-Cisneros, Noemies_ES
AutorEsquivel-Hernandez, Diego Armandoes_ES
AutorGarcia-Villalobos, Gloriaes_ES
AutorGaribay-Nieto, Nayelyes_ES
AutorGarcia-Oropesa, Esperanza Milagroses_ES
AutorHernandez-Martinez, Juan Carloses_ES
AutorLopez-Sosa, Elena Beatrizes_ES
AutorMaldonado, Carloses_ES
AutorMartinez, Davides_ES
AutorMembreno, Joshuaes_ES
AutorMoctezuma-Chavez, Oscar Omares_ES
AutorMunguia-Cisneros, Claudia X.es_ES
AutorNava-Gonzalez, Edna J.es_ES
AutorPerales-Torres, Adriana L.es_ES
AutorPerez-Garcia, Adolfoes_ES
AutorRivera-Marrero, Hectores_ES
AutorValdez, Alishaes_ES
AutorVazquez-Chavez, Alfonso Alejandroes_ES
AutorRamirez-Pfeiffer, Carloses_ES
AutorCarter, Kathleen V.es_ES
AutorTapia, Beatrizes_ES
AutorVela, Leoneles_ES
AutorLopez-Alvarenga, Juan Carloses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1186/s12916-024-03744-x
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen22es_ES

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