The effect of androgen excess on maternal metabolism, placental function and fetal growth in obese dams

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:40Z
Fecha de publicación2017-01-01
ResumenPregnant women with polycystic ovary syndrome (PCOS) are often overweight or obese. To study the effects of maternal androgen excess in obese dams on metabolism, placental function and fetal growth, female C57Bl6J mice were fed a control (CD) or a high fat/high sucrose (HF/HS) diet for 4-10 weeks, and then mated. On gestational day (GD) 15.5-17.5, dams were injected with dihydrotestosterone (CD-DHT, HF/HS-DHT) or a vehicle (CD-Veh, HF/HS-Veh). HF/HS dams had higher fat content, both before mating and on GD18.5, with no difference in glucose homeostasis, whereas the insulin sensitivity was higher in DHT-exposed dams. Compared to the CD groups, the livers from HF/HS dams weighed more on GD18.5, the triglyceride content was higher, and there was a dysregulation of liver enzymes related to lipogenesis and higher mRNA expression of Fitm1. Fetuses from HF/HS-Veh dams had lower liver triglyceride content and mRNA expression of Srebf1c. Maternal DHT exposure, regardless of diet, decreased fetal liver Pparg mRNA expression and increased placental androgen receptor protein expression. Maternal diet-induced obesity, together with androgen excess, affects maternal and fetal liver function as demonstrated by increased triglyceride content and dysfunctional expression of enzymes and transcription factors involved in de novo lipogenesis and fat storage.es_ES
Doihttps://doi.org/10.1038/s41598-017-08559-wes_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5479
Idiomaenes_ES
EditorialNATURE PORTFOLIOes_ES
RelaciónScientific Reportses_ES
URL relacionadohttps://doi.org/10.1038/s41598-017-08559-wes_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteScientific Reports
TítuloThe effect of androgen excess on maternal metabolism, placental function and fetal growth in obese damses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorFornes, Romina
AutorMaliqueo, Manuel
AutorHu, Min
AutorHadi, Laila
AutorJimenez-Andrade, Juan M.
AutorEbefors, Kerstin
AutorNystrom, Jenny
AutorLabrie, Fernand
AutorJansson, Thomas
AutorBenrick, Anna
AutorStener-Victorin, Elisabet
AutorFornes, Rominaes_ES
AutorMaliqueo, Manueles_ES
AutorHu, Mines_ES
AutorHadi, Lailaes_ES
AutorJimenez-Andrade, Juan M.es_ES
AutorEbefors, Kerstines_ES
AutorNystrom, Jennyes_ES
AutorLabrie, Fernandes_ES
AutorJansson, Thomases_ES
AutorBenrick, Annaes_ES
AutorStener-Victorin, Elisabetes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.1038/s41598-017-08559-w
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen7es_ES

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