Lack of association of the calpain-10 Indel-19 variant with chronic diseases in a Mexican population

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:32Z
Fecha de publicación2025-01-01
ResumenObjectiveThe CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic disorders, mainly obesity. This study aimed to investigate the association between the CAPN10 Indel-19 variant and some clinical parameters in a Mexican population sample. We recruited 426 apparently healthy individuals over 30 years of age. We obtained anthropometric data, arterial pressure, fasting biochemical parameters, and genotyping for CAPN10 Indel-19. ResultsThe frequency of overweight and obesity was 82.9\%, hypertension 8\%, hypercholesterolemia 14.8\%, hypertriglyceridemia 31.9\%, impaired plasma glucose 23.9\%, and diabetes 4.7\%. The genotype frequencies were 13.1\%, 47.9\%, and 39\% for del/del, del/ins, and ins/ins, respectively; the allele frequencies were 37.1\% for the del allele and 62.9\% for the ins allele. The analysis of the continuous parameters according to the genotypes showed no significant differences. However, when these parameters were dichotomized (reference group versus high-level group), the ins allele was associated with a protective effect against high arterial pressure (prehypertension and hypertension). It is unclear whether the CAPN10 Indel-19 variant increases the risk of chronic diseases, so further studies are needed to confirm or refute this issue.es_ES
Doihttps://doi.org/10.1186/s13104-025-07184-5es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4363
Idiomaenes_ES
EditorialSPRINGERNATUREes_ES
RelaciónBMC Research Noteses_ES
URL relacionadohttps://doi.org/10.1186/s13104-025-07184-5es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBMC Research Notes
Palabra claveCAPN10 genees_ES
Palabra claveIndel-19 variantes_ES
Palabra claveChronic diseaseses_ES
TítuloLack of association of the calpain-10 Indel-19 variant with chronic diseases in a Mexican populationes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMeza-Espinoza, Juan Pablo
AutorZavala-Rubio, Juan de Dios
AutorLeal-Ugarte, Evelia
AutorPicos-Cardenas, Veronica Judith
AutorContreras-Gutierrez, Jose Alfredo
AutorMaduena-Molina, Jesus
AutorCamberos-Barraza, Josue
AutorCervin-Serrano, Salvador
AutorVarela German, Maria Lourdes
AutorMeza-Espinoza, Juan Pabloes_ES
AutorZavala-Rubio, Juan de Dioses_ES
AutorLeal-Ugarte, Eveliaes_ES
AutorPicos-Cardenas, Veronica Judithes_ES
AutorContreras-Gutierrez, Jose Alfredoes_ES
AutorMaduena-Molina, Jesuses_ES
AutorCamberos-Barraza, Josuees_ES
AutorCervin-Serrano, Salvadores_ES
AutorVarela German, Maria Lourdeses_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1186/s13104-025-07184-5
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen18es_ES

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