Virtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phase

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:13Z
Fecha de publicación2021-01-01
ResumenInfectious diseases caused by intestinal protozoan, such as Entamoeba histolytica (E. histolytica) and Giardia lamblia (G. lamblia) are a worldwide public health issue. They affect more than 70 million people every year. They colonize intestines causing primarily diarrhea; nevertheless, these infections can lead to more serious complications. The treatment of choice, metronidazole, is in doubt due to adverse effects and resistance. Therefore, there is a need for new compounds against these parasites. In this work, a structure-based virtual screening of FDA-approved drugs was performed to identify compounds with antiprotozoal activity. The glycolytic enzyme triosephosphate isomerase, present in both E. histolytica and G. lamblia, was used as the drug target. The compounds with the best average docking score on both structures were selected for the in vitro evaluation. Three compounds, chlorhexidine, tolcapone, and imatinib, were capable of inhibit growth on G. lamblia trophozoites (0.05–4.935 μg/mL), while folic acid showed activity against E. histolytica (0.186 μg/mL) and G. lamblia (5.342 μg/mL).es_ES
Doihttps://doi.org/10.3390/ijms22115943es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2168
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms22115943es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
TítuloVirtual Screening of FDA-Approved Drugs against Triose Phosphate Isomerase from Entamoeba histolytica and Giardia lamblia Identifies Inhibitors of Their Trophozoite Growth Phasees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorJuárez-Saldivar, Alfredo
AutorBarbosa-Cabrera, Elizabeth
AutorLara-Ramírez, Edgar E.
AutorPaz-González, Alma D.
AutorMartínez-Vázquez, Ana V.
AutorBocanegra-García, Virgilio
AutorPalos, Isidro
AutorCampillo, Nuria E.
AutorRivera, Gildardo
AutorJuárez-Saldivar, Alfredoes_ES
AutorBarbosa-Cabrera, Elizabethes_ES
AutorLara-Ramírez, Edgar E.es_ES
AutorPaz-González, Alma D.es_ES
AutorMartínez-Vázquez, Ana V.es_ES
AutorBocanegra-García, Virgilioes_ES
AutorPalos, Isidroes_ES
AutorCampillo, Nuria E.es_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número11es_ES
Rango de páginas5943es_ES
URL relacionadahttps://doi.org/10.3390/ijms22115943
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen22es_ES

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