Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:55Z
Fecha de publicación2007-01-01
ResumenObjectives: To analyse the clinical value of procalcitonin (PCT), C-reactive protein (CRP) and leucocyte count in the diagnosis of paediatric sepsis and in the stratification of patients according to severity. Design: Prospective, observational study. Setting: Paediatric intensive care unit (PICU). Patients: Ninety-four children. Measurement and results: Leucocyte count, PCT and CRP were measured when considered necessary during the PICU stay. Patients were classified, when PCT and CRP were measured, into one of six categories (negative, SIRS, localized infection, sepsis, severe sepsis, and septic shock) according to the definitions of the American College of Chest Physicians/Society of Critical Care Medicine. A total of 359 patient day episodes were obtained. Leucocyte count did not differ across the six diagnostic classes considered. Median plasma PCT concentrations were 0.17, 0.43, 0.79, 1.80, 15.40 and 19.13 ng/ml in negative, systemic inflammatory response syndrome (SIRS), localized infection, sepsis, severe sepsis, and septic shock groups, respectively, whereas median plasma CRP concentrations were 1.35, 3.80, 6.45, 5.70, 7.60 and 16.2 mg/dl, respectively. The area under the ROC curve for the diagnosis of septic patients was 0.532 for leucocyte count (95\% CI, 0.462-0.602), 0.750 for CRP (95\% CI, 0.699-0.802) and 0.912 for PCT (95\% CI, 0.882-0.943). We obtained four groups using CRP values and five groups using PCT values that classified a significant percentage of patients according to the severity of the different SIRS groups. Conclusions: PCT is a better diagnostic marker of sepsis in critically ill children than CRP. The CRP, and especially PCT, may become a helpful clinical tool to stratify patients with SIRS according to disease severity.es_ES
Doihttps://doi.org/10.1007/s00134-006-0509-7es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4770
Idiomaenes_ES
EditorialSPRINGERes_ES
RelaciónIntensive Care Medicinees_ES
URL relacionadohttps://doi.org/10.1007/s00134-006-0509-7es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteIntensive Care Medicine
Palabra clavesystemic inflammatory response syndromees_ES
Palabra clavesepsises_ES
Palabra claveshockes_ES
Palabra claveprocalcitonines_ES
Palabra claveC-reactive proteines_ES
TítuloProcalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill childrenes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRey, Corsino
AutorLos Arcos, Marta
AutorConcha, Andres
AutorMedina, Alberto
AutorPrieto, Soledad
AutorMartinez, Pablo
AutorPrieto, Belen
AutorRey, Corsinoes_ES
AutorLos Arcos, Martaes_ES
AutorConcha, Andreses_ES
AutorMedina, Albertoes_ES
AutorPrieto, Soledades_ES
AutorMartinez, Pabloes_ES
AutorPrieto, Belenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas477-484es_ES
URL relacionadahttps://doi.org/10.1007/s00134-006-0509-7
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen33es_ES

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