Strawberry, Blueberry, and Strawberry-Blueberry Blend Beverages Prevent Hepatic Steatosis in Obese Rats by Modulating Key Genes Involved in Lipid Metabolism

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:59Z
Fecha de publicación2023-01-01
ResumenThere is an increasing interest in developing natural herb-infused functional beverages with health benefits; therefore, in this study, we aimed to evaluate the effect of strawberry, blueberry, and strawberry-blueberry blend decoction-based functional beverages on obesity-related metabolic alterations in high-fat and high-fructose diet-fed rats. The administration of the three berry-based beverages for eighteen weeks prevented the development of hypertriglyceridemia in obese rats (1.29–1.78-fold) and hepatic triglyceride accumulation (1.38–1.61-fold), preventing the development of hepatic steatosis. Furthermore, all beverages significantly down-regulated Fasn hepatic expression, whereas the strawberry beverage showed the greatest down-regulation of Acaca, involved in fatty acid de novo synthesis. Moreover, the strawberry beverage showed the most significant up-regulation of hepatic Cpt1 and Acadm (fatty acid β-oxidation). In contrast, the blueberry beverage showed the most significant down-regulation of hepatic Fatp5 and Cd36 (fatty acid intracellular transport). Nevertheless, no beneficial effect was observed on biometric measurements, adipose tissue composition, and insulin resistance. On the other hand, several urolithins and their derivatives, and other urinary polyphenol metabolites were identified after the strawberry-based beverages supplementation. In contrast, enterolactone was found significantly increase after the intake of blueberry-based beverages. These results demonstrate that functional beverages elaborated with berry fruits prevent diet-induced hypertriglyceridemia and hepatic steatosis by modulating critical genes involved in fatty acid hepatic metabolism.es_ES
Doihttps://doi.org/10.3390/ijerph20054418es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5734
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Environmental Research and Public Healthes_ES
URL relacionadohttps://doi.org/10.3390/ijerph20054418es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Environmental Research and Public Health
Palabra claveberry fruitses_ES
Palabra clavefunctional beverageses_ES
Palabra clavehepatic steatosises_ES
Palabra claveobesityes_ES
Palabra claveratses_ES
Palabra claveurinary polyphenolses_ES
TítuloStrawberry, Blueberry, and Strawberry-Blueberry Blend Beverages Prevent Hepatic Steatosis in Obese Rats by Modulating Key Genes Involved in Lipid Metabolismes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorSotelo-González, Ana María
AutorReynoso-Camacho, Rosalía
AutorHernández-Calvillo, Ana Karina
AutorCastañón-Servín, Ana Paola
AutorGarcía-Gutiérrez, David Gustavo
AutorGómez-Velázquez, Haiku Daniel de Jesús
AutorMartínez-Maldonado, Miguel Ángel
Autorde los Ríos, Ericka Alejandra
AutorPérez-Ramírez, Iza Fernanda
AutorSotelo-González, Ana Maríaes_ES
AutorReynoso-Camacho, Rosalíaes_ES
AutorHernández-Calvillo, Ana Karinaes_ES
AutorCastañón-Servín, Ana Paolaes_ES
AutorGarcía-Gutiérrez, David Gustavoes_ES
AutorGómez-Velázquez, Haiku Daniel de Jesúses_ES
AutorMartínez-Maldonado, Miguel Ángeles_ES
Autorde los Ríos, Ericka Alejandraes_ES
AutorPérez-Ramírez, Iza Fernandaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
URL relacionadahttps://doi.org/10.3390/ijerph20054418
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen20es_ES

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