Insecticidal Activity of Organic Extracts of Solidago graminifolia and Its Main Metabolites (Quercetin and Chlorogenic Acid) against Spodoptera frugiperda: An In Vitro and In Silico Approach

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:03Z
Fecha de publicación2022-01-01
ResumenSpodoptera frugiperda (S. frugiperda) remains a global primary pest of maize. Therefore, new options to combat this pest are necessary. In this study, the insecticidal activity of three crude foliar extracts (ethanol, dichloromethane, and hexane) and their main secondary metabolites (quercetin and chlorogenic acid) of the species Solidago graminifolia (S. graminifolia) by ingestion bioassays against S. frugiperda larvae was analyzed. Additionally, the extracts were phytochemically elucidated by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) analysis. Finally, an in silico study of the potential interaction of quercetin on S. frugiperda acetylcholinesterase was performed. Organic extracts were obtained in the range from 5 to 33%. The ethanolic extract caused higher mortality (81%) with a half-maximal lethal concentration (LC50) of 0.496 mg/mL. Flavonoid secondary metabolites such as hyperoside, quercetin, isoquercetin, kaempferol, and avicularin and some phenolic acids such as chlorogenic acid, solidagoic acid, gallic acid, hexoside, and rosmarinic acid were identified. In particular, quercetin had an LC50 of 0.157 mg/mL, and chlorogenic acid did not have insecticidal activity but showed an antagonistic effect on quercetin. The molecular docking analysis of quercetin on the active site of S. frugiperda acetylcholinesterase showed a −5.4 kcal/mol binding energy value, lower than acetylcholine and chlorpyrifos (−4.45 and −4.46 kcal/mol, respectively). Additionally, the interactions profile showed that quercetin had π–π interactions with amino acids W198, Y235, and H553 on the active site.es_ES
Doihttps://doi.org/10.3390/molecules27103325es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2000
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónMoleculeses_ES
URL relacionadohttps://doi.org/10.3390/molecules27103325es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMolecules
TítuloInsecticidal Activity of Organic Extracts of Solidago graminifolia and Its Main Metabolites (Quercetin and Chlorogenic Acid) against Spodoptera frugiperda: An In Vitro and In Silico Approaches_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorHerrera-Mayorga, Verónica
AutorGuerrero-Sánchez, José Alfredo
AutorMéndez-Álvarez, Domingo
AutorParedes-Sánchez, Francisco A.
AutorRodríguez-Duran, Luis Víctor
AutorNiño-García, Nohemí
AutorPaz-González, Alma D.
AutorRivera, Gildardo
AutorHerrera-Mayorga, Verónicaes_ES
AutorGuerrero-Sánchez, José Alfredoes_ES
AutorMéndez-Álvarez, Domingoes_ES
AutorParedes-Sánchez, Francisco A.es_ES
AutorRodríguez-Duran, Luis Víctores_ES
AutorNiño-García, Nohemíes_ES
AutorPaz-González, Alma D.es_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número10es_ES
Rango de páginas3325es_ES
URL relacionadahttps://doi.org/10.3390/molecules27103325
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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