Repurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the Substantia nigra

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:26Z
Fecha de publicación2023-01-01
ResumenParkinson's disease is a neurodegenerative disorder characterized by oxidative stress and immune activation in the nigro-striatal pathway. Simvastatin regulates cholesterol metabolism and protects from atherosclerosis disease. Simvastatin-tween 80 was administered 7 days before sterotaxic intrastriatal administration of MPP+ (1-methyl-4-phenylpyridine) in rats. Fluorescent lipidic product formation, dopamine levels, and circling behavior were considered damage markers. Twenty-four hours and six days after, the animal group lesioned with MPP+ showed significant damage in relation to the control group. Animals pretreated with simvastatin significantly reduced the MPP+-induced damage compared to the MPP+ treated group. As apoptosis promotes neuroinflammation and neuronal degeneration in Parkinson's disease, and since there is not currently a proteomic map of the nigro-striatum of rats and assuming a high homology among the identified proteins in other rat tissues, we based the search for rat protein homologs related to the establishment of inflammation response. We demonstrate that most proteins related to inflammation decreased in the simvastatin-treated rats. Furthermore, differential expression of antioxidant enzymes in striated tissue of rat brains was found in response to simvastatin. These results suggest that simvastatin could prevent striatal MPP+-induced damage and, for the first time, suggest that the molecular mechanisms involved in this have a protective effect.es_ES
Doihttps://doi.org/10.3390/ijms241310414es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5276
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms241310414es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
Palabra claveParkinson's diseasees_ES
Palabra claveMPP+es_ES
Palabra claveneuroinflammationes_ES
Palabra claveoxidative stress proinflammatory cytokineses_ES
TítuloRepurposing Simvastatin in Parkinson's Disease Model: Protection Is throughout Modulation of the Neuro-Inflammatory Response in the Substantia nigraes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRubio-Osornio, Moises
AutorGomez-De Leon, Carmen T.
AutorMontes, Sergio
AutorRubio, Carmen
AutorRios, Camilo
AutorMonroy, Antonio
AutorMorales-Montor, Jorge
AutorRubio-Osornio, Moiseses_ES
AutorGomez-De Leon, Carmen T.es_ES
AutorMontes, Sergioes_ES
AutorRubio, Carmenes_ES
AutorRios, Camiloes_ES
AutorMonroy, Antonioes_ES
AutorMorales-Montor, Jorgees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número13es_ES
URL relacionadahttps://doi.org/10.3390/ijms241310414
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen24es_ES

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