Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:38Z
Fecha de publicación2020-01-01
ResumenIntroduction: In light of the current COVID-19 pandemic, during which the world is confronted with a new, highly contagious virus that suppresses innate immunity as one of its initial virulence mechanisms, thus escaping from first-line human defense mechanisms, enhancing innate immunity seems a good preventive strategy. Methods: Without the intention to write an official systematic review, but more to give an overview of possible strategies, in this review article we discuss several interventions that might stimulate innate immunity and thus our defense against (viral) respiratory tract infections. Some of these interventions can also stimulate the adaptive Tand B-cell responses, but our main focus is on the innate part of immunity. We divide the reviewed interventions into: 1) lifestyle related (exercise, >7 h sleep, forest walking, meditation/mindfulness, vitamin supplementation); 2) Nonspecific immune stimulants (letting fever advance, bacterial vaccines, probiotics, dialyzable leukocyte extract, pidotimod), and 3) specific vaccines with heterologous effect (BCG vaccine, mumps-measles-rubeola vaccine, etc). Results: For each of these interventions we briefly comment on their definition, possible mechanisms and evidence of clinical efficacy or lack of it, especially focusing on respiratory tract infections, viral infections, and eventually a reduced mortality in severe respiratory infections in the intensive care unit. At the end, a summary table demonstrates the best trials supporting (or not) clinical evidence. Conclusion: Several interventions have some degree of evidence for enhancing the innate immune response and thus conveying possible benefit, but specific trials in COVID-19 should be conducted to support solid recommendations.es_ES
Doihttps://doi.org/10.1016/j.waojou.2020.100476es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5428
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónWorld Allergy Organization Journales_ES
URL relacionadohttps://doi.org/10.1016/j.waojou.2020.100476es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteWorld Allergy Organization Journal
Palabra claveCOVID-19es_ES
Palabra claveImmune responsees_ES
Palabra claveInnatees_ES
Palabra claveExercisees_ES
Palabra claveMindfulnesses_ES
Palabra claveSleepes_ES
Palabra claveBacterial vaccinees_ES
Palabra claveTrained immunityes_ES
Palabra claveBacillus calmette-guerines_ES
Palabra claveMMRes_ES
Palabra claveNK-Celles_ES
TítuloEnhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictionses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLarenas-Linnemann, Desiree
AutorRodriguez-Perez, Noel
AutorArias-Cruz, Alfredo
AutorBlandon-Vijil, Maria Virginia
AutorDel Rio-Navarro, Blanca E.
AutorEstrada-Cardona, Alan
AutorGereda, Jose E.
AutorLuna-Pech, Jorge A.
AutorNavarrete-Rodriguez, Elsy Maureen
AutorOnuma-Takane, Ernesto
AutorPozo-Beltran, Cesar Fireth
AutorRojo-Gutierrez, Maria Isabel
AutorLarenas-Linnemann, Desireees_ES
AutorRodriguez-Perez, Noeles_ES
AutorArias-Cruz, Alfredoes_ES
AutorBlandon-Vijil, Maria Virginiaes_ES
AutorDel Rio-Navarro, Blanca E.es_ES
AutorEstrada-Cardona, Alanes_ES
AutorGereda, Jose E.es_ES
AutorLuna-Pech, Jorge A.es_ES
AutorNavarrete-Rodriguez, Elsy Maureenes_ES
AutorOnuma-Takane, Ernestoes_ES
AutorPozo-Beltran, Cesar Firethes_ES
AutorRojo-Gutierrez, Maria Isabeles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número11es_ES
URL relacionadahttps://doi.org/10.1016/j.waojou.2020.100476
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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