Association between Genetic Variant rs2267716 of CRHR2 Gene with Colorectal Cancer

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:07Z
Fecha de publicación2021-12-30
ResumenColorectal cancer (CRC) is the third most common cancer and one of the main causes of death around the world. Multiple lines of evidence have suggested the role of the corticotropin-releasing hormone (CRH) family in CRC induction, including the low expression of corticotropin-releasing hormone receptor 2 ( CRHR2), which is an angiogenesis inhibitor and inflammatory modulator. Previous research suggests that CRHR2 expression in colonic intestinal cells can regulate migration, proliferation and apoptosis through the modulation of several pathways. The aim of this study was to analyze the association of the rs10250835, rs2267716 and rs2267717 variants of CRHR2 gene with CRC in the Mexican population in order to consider its predictive value in CRC. This cross-sectional study included a group of 187 unrelated patients with sporadic CRC and a control group of 191 healthy blood donors. DNA extraction from peripheral blood was carried out using the Miller method. Identification of the rs10250835 variant was performed using PCR-restriction fragment length polymorphism (RFLP) and the rs2267716 and rs2267717 variants using TaqMan allelic discrimination assay. The minor allele homozygous CC of the rs2267716 variant of CRHR2 showed significant difference between CRC and control group (p=0.025), as well as the GCA haplotype (p=0.007), corresponding to the rs10250835, rs2267716 and rs2267717 variants, respectively. Our results suggest that the rs2267716 variant and GCA haplotype of CRHR2 represent a risk factor for CRC development in Mexican patients.es_ES
Doihttps://doi.org/10.1136/jim-2021-002047es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2816
Idiomaenes_ES
EditorialSAGE Publishinges_ES
RelaciónJournal of Investigative Medicinees_ES
URL relacionadohttps://doi.org/10.1136/jim-2021-002047es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Investigative Medicine
Palabra claveColorectal canceres_ES
Palabra claveAllelees_ES
Palabra claveBiologyes_ES
Palabra claveHaplotypees_ES
Palabra clavePopulationes_ES
Palabra claveCanceres_ES
Palabra claveInternal medicinees_ES
Palabra claveGenees_ES
Palabra claveCancer researches_ES
Palabra claveOncologyes_ES
Palabra claveGeneticses_ES
Palabra claveMedicinees_ES
ClasificaciónHormonal Regulation and Hypertensiones_ES
TítuloAssociation between Genetic Variant rs2267716 of CRHR2 Gene with Colorectal Canceres_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorRamírez-Guerrero, Angélica Araceli
AutorGonzález-Villaseñor, Christian O.
AutorLeal‐Ugarte, Evelia
AutorGutiérrez‐Angulo, Melva
AutorRamírez-Flores, Mario
AutorDelgado‐Enciso, Iván
AutorMacías‐Gómez, Nelly Margarita
AutorRamírez-Guerrero, Angélica Aracelies_ES
AutorGonzález-Villaseñor, Christian O.es_ES
AutorLeal‐Ugarte, Eveliaes_ES
AutorGutiérrez‐Angulo, Melvaes_ES
AutorRamírez-Flores, Marioes_ES
AutorDelgado‐Enciso, Ivánes_ES
AutorMacías‐Gómez, Nelly Margaritaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas947-952es_ES
URL relacionadahttps://doi.org/10.1136/jim-2021-002047
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen70es_ES

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