Chemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemia

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:38Z
Fecha de publicación2017-01-01
ResumenBackground: Chemotherapy-induced peripheral neuropathy (CIPN) is frequent in children with acute lymphoblastic leukemia (ALL). Neurological manifestations can be grouped into one of the three functional divisions of the peripheral nervous system (PNS): sensory, motor and autonomic. One of the chemotherapeutic agents used in ALL is vincristine which has been associated with neuropathy in these children. This type of neuropathy can be transient but also leave permanent sequels that decrease patient's quality of life. Objectives: To know the frequency and type of neuropathy induced by chemotherapy in a subpopulation of Mexican pediatric patients with acute lymphoblastic leukemia. Methods: A cross-sectional study was conducted. There were included all pediatric patients with ALL diagnosed de novo from 2010 to December 31, 2013 who met the selection criteria. Descriptive statistics were used to determine the frequency and type of CIPN and information was described according to different clinical variables, type of treatment, risk classification, and ALL subtype according to the immunophenotype. Results: A total of 32 patients with acute lymphoblastic leukemia were included, mainly of early pre-B immunophenotype (93.8\%), being 59.4\% classified as high risk patients at the time of diagnosis. CIPN of sensory type was 78.1\%, motor 34.3\% and autonomic 40.6\%. A significant proportion of patients (46.9\%) were examined during maintenance phase. Conclusions: To our knowledge, this is the first study to report the frequency and type of CIPN in a subpopulation of Mexican children with acute lymphoblastic leukemia. Frequency of CIPN was higher than that reported in other populations. By considering that prognosis of a patient presenting CIPN could be considered as favorable after treatment suspension (in most cases), it is not always reversible and affects patient's quality of life. Therefore, it is necessary for all patients with ALL to be periodically monitored during treatment through neurological examination for detecting and immediately initiating their rehabilitation treatment.es_ES
Doihttps://doi.org/10.5812/ijp.11844es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4476
Idiomaenes_ES
EditorialKOWSAR CORPes_ES
RelaciónIranian Journal of Pediatricses_ES
URL relacionadohttps://doi.org/10.5812/ijp.11844es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteIranian Journal of Pediatrics
Palabra claveAntineoplastic Agentses_ES
Palabra claveChildrenes_ES
Palabra claveLeukemiaes_ES
Palabra clavePeripheral Nervous System Diseaseses_ES
TítuloChemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemiaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorJesus Vivas-Rosales, Irving
AutorGarcia-Saavedra, Liliana
AutorAlfonso Martin-Trejo, Jorge
AutorManuel Mejia-Arangure, Juan
AutorPatricia Victorio-Garcia, Nora
AutorHerrera-Landero, Alejandro
AutorCarlos Nunz-Enriquez, Juan
AutorJesus Vivas-Rosales, Irvinges_ES
AutorGarcia-Saavedra, Lilianaes_ES
AutorAlfonso Martin-Trejo, Jorgees_ES
AutorManuel Mejia-Arangure, Juanes_ES
AutorPatricia Victorio-Garcia, Noraes_ES
AutorHerrera-Landero, Alejandroes_ES
AutorCarlos Nunz-Enriquez, Juanes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número5es_ES
URL relacionadahttps://doi.org/10.5812/ijp.11844
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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