THEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS - 12TH MUTATIONAL AND NON-MUTATIONAL MECHANISM AS SUBSETS OF A MORE GENERAL MECHANISM .A. ETHIONINE

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:21Z
Fecha de publicación1984-01-01
ResumenThe ethionine-induced genetic derepression mechanism is a secondary process that occurs after the S-adenosyl-L methionine pool concentrations are lowered to critical levels. Although DNA methylation correlated with genetic activity, the times observed for inducement (3 days) of the .alpha.-fetoprotein gene and its reversibility (within 7 days) does not make it likely that alterations in the methylated status of DNA is involved. The specific mechanism is theorized to be as follows: the adenine moiety of S-adenosyl-L-methionine base pairs with thymine of a specific structural area of the .alpha.-fetoprotein gene. The process is visualized as a frequent event during moments of structural relaxation of an otherwise hyperspiralized condition of the chromatin. This weak hydrogen bonding situation allows the methylation by protein methylases of a precursor chromatin protein that after methylation by the S-adenosyl-L methionine which is base-paired to the specific DNA site, conformationally is set or locked into place and acts as a specific repressor for the .alpha.-fetoprotein gene. This subsequently disallows RNA polymerase activity of the region. During turnover of this chromatin protein the replacement of the methylated repressor is normally maintained. If the S-adenosyl-L-methionine pool concentration is lowered to a level below that required for base-pairing by the adenine moiety, the repressed conformational condition of the .alpha.-fetoprotein gene is altered allowing transcription. In this manner, the correlation between low S-adenosyl-L-methionine and .alpha.-fetoprotein synthesis can be made.es_ES
Doihttps://doi.org/10.1016/0306-9877(84)90022-7es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4192
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónMedical Hypotheseses_ES
URL relacionadohttps://doi.org/10.1016/0306-9877(84)90022-7es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteMedical Hypotheses
TítuloTHEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS - 12TH MUTATIONAL AND NON-MUTATIONAL MECHANISM AS SUBSETS OF A MORE GENERAL MECHANISM .A. ETHIONINEes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorHANCOCK, RL
AutorHANCOCK, RLes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas323-331es_ES
URL relacionadahttps://doi.org/10.1016/0306-9877(84)90022-7
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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