Expression of the Transcription Factor FOXP3 in Human Peripheral Blood B-Cell Subtypes (CD19+CD39+ and CD19+CD39-) and Evaluation of Their Regulatory Function

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:40Z
Fecha de publicación2025-06-11
ResumenIntroduction The aim of this study was to evaluate FOXP3 expression in CD19+CD39+ and CD19+CD39− B cells, and to investigate its potential regulatory role.Methods Peripheral B cells were obtained from 25 volunteers. FOXP3 expression at the mRNA and protein levels was analyzed in CD19+CD39+ and CD19+CD39− B cells by FACS and RT-qPCR. Suppressive activity was assessed through co-cultures of PBMC with CD19+CD39+ and CD19+CD39− B cells stimulated with anti-CD3/CD28, evaluating T cell proliferation and the percentage of Th1 cells.Results The percentage of CD19+CD39+ FOXP3+ B cells was higher compared to other phenotypes. There was a positive correlation between FOXP3 and CD39 in CD19+ B cells. FOXP3 mRNA was increased in CD19+CD39+ B cells compared to CD19+CD39− B cells. CD19+CD39− B cells reduced the proliferation, the percentage of Th1 cells, and expressed higher IL-10 mRNA compared to CD19+CD39+ B cells. B cell phenotypes were inversely associated with Th1 cells and CRP. CD19+CD39− was associated with HOMA-β. CD19+CD39+ was inversely associated with HbA1c.Discussion FOXP3 is expressed on both CD19+CD39− and CD19+CD39+ B lymphocytes. CD19+CD39− cells showed high levels of IL-10 and low levels of FOXP3 mRNA. CD19+CD39− B cells decreased the Th1 cells and were associated with β-cell function.es_ES
Doihttps://doi.org/10.1080/08820139.2025.2515411es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/3339
Idiomaenes_ES
EditorialTaylor & Francises_ES
RelaciónImmunological Investigationses_ES
URL relacionadohttps://doi.org/10.1080/08820139.2025.2515411es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteImmunological Investigations
Palabra claveCD19es_ES
Palabra claveTranscription factores_ES
Palabra clavePeripheral bloodes_ES
Palabra claveFOXP3es_ES
Palabra claveBiologyes_ES
Palabra claveImmunologyes_ES
Palabra claveFunction (biology)es_ES
Palabra claveCell biologyes_ES
Palabra claveGeneticses_ES
Palabra claveGenees_ES
Palabra claveImmune systemes_ES
ClasificaciónT-cell and B-cell Immunologyes_ES
TítuloExpression of the Transcription Factor FOXP3 in Human Peripheral Blood B-Cell Subtypes (CD19+CD39+ and CD19+CD39-) and Evaluation of Their Regulatory Functiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCardenas-Juarez, Abraham
AutorUresti‐Rivera, Edith Elena
AutorOchoa-González, Fátima de Lourdes
AutorLira-Hernández, Flor Itzel
AutorLara‐Ramírez, Edgar E.
AutorVargas‐Morales, Juan Manuel
AutorRivas‐Santiago, Bruno
AutorPortales‐Pérez, Diana Patricia
AutorGarcía-Hernández, Mariana Haydee
AutorCardenas-Juarez, Abrahames_ES
AutorUresti‐Rivera, Edith Elenaes_ES
AutorOchoa-González, Fátima de Lourdeses_ES
AutorLira-Hernández, Flor Itzeles_ES
AutorLara‐Ramírez, Edgar E.es_ES
AutorVargas‐Morales, Juan Manueles_ES
AutorRivas‐Santiago, Brunoes_ES
AutorPortales‐Pérez, Diana Patriciaes_ES
AutorGarcía-Hernández, Mariana Haydeees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
Rango de páginas1110-1125es_ES
URL relacionadahttps://doi.org/10.1080/08820139.2025.2515411
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen54es_ES

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