In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:07Z
Fecha de publicación2015-01-01
ResumenBerberis hartwegii Benth., Berberidaceae, Hamelia patens Jacq., Rubiaceae, Dendropanax arboreus (L.) Decne \& Planch., Araliaceae, Erythrina herbacea L., Fabaceae, and Zanthoxylum caribaeum Lam., Rutaceae, acetone extracts were selected on the basis of their use in traditional Mexican medicine to treat scabies or skin diseases. Anti-dermatophyte activity in vitro was evaluated using the agar dilution assay, and the therapeutic efficacy of B. hartwegii and Z. caribaeum were tested against experimental tinea pedis. The infected animals were treated intragastrically daily for seven days with 2.5 and 5 mg/kg of acetone extracts. The acetone extract of H. patens exhibited 100\% growth inhibition against T. mentagrophytes and E. floccosum at 100.0 and 50.0 mu g/ml, respectively, and B. hartwegii inhibited growth of M. canis and T. mentagrophytes at 100.0 mu g/ml. Effective treatments with 2.5 mg/kg of Z. caribaeum and B. hartwegii extract were comparable with 1 mg/kg of clotrimazole in mice. Liver profile tests and histological analyses did not exhibit any signs of toxicity and the Ames test indicated that both extracts were safe when evaluated in strains TA98, TA100 and TA102. Our results suggest the potential for the future development of new antifungal drugs from B. hartwegii or Z. caribaeum. (C) 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.bjp.2014.12.003es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4951
Idiomaenes_ES
EditorialSOC BRASILEIRA FARMACOGNOSIAes_ES
RelaciónRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosyes_ES
URL relacionadohttps://doi.org/10.1016/j.bjp.2014.12.003es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy
Palabra claveAntifungal activityes_ES
Palabra claveBerberis hartwegiies_ES
Palabra claveHamelia-patenses_ES
Palabra claveZanthoxylum caribaeumes_ES
TítuloIn vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicinees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCornejo-Garrido, Jorge
AutorSalinas-Sandoval, Martha
AutorDiaz-Lopez, Arely
AutorJacquez-Rios, Patricia
AutorArriaga-Alba, Myriam
AutorOrdaz-Pichardo, Cynthia
AutorCornejo-Garrido, Jorgees_ES
AutorSalinas-Sandoval, Marthaes_ES
AutorDiaz-Lopez, Arelyes_ES
AutorJacquez-Rios, Patriciaes_ES
AutorArriaga-Alba, Myriames_ES
AutorOrdaz-Pichardo, Cynthiaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas22-28es_ES
URL relacionadahttps://doi.org/10.1016/j.bjp.2014.12.003
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen25es_ES

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