Perinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the brain

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:57Z
Fecha de publicación2024-01-01
ResumenLead (Pb) exposure during perinatal development alters testosterone (T) concentrations and delays puberty in children and laboratory rodents. In addition, exposure to the metal during adult life decreases T and libido in men and affects male reproductive behaviour (MRB) in rats. MRB is regulated by various brain nuclei including the medial preoptic area (MPOa) and the medial amygdala (MeA), in which T and oestradiol (E2) act through their respective androgen (AR) and oestrogen (ER) receptors. However, the mechanism by which MRB is affected by Pb exposure is not known. The objectives of the present study were to evaluate whether perinatal Pb exposure affects MRB and the number of cells immunoreactive to AR and ER alpha in the MPOa and the MeA. Male Wistar rats exposed to Pb (320 ppm) in drinking water from the beginning of pregnancy until weaning were used. The experimental group experienced significant alterations in MRB, an important decrease in T and E2 concentrations, and a significant increase in Pb concentrations in the blood, MPOa (hypothalamus) and MeA. In addition, in the studied areas the number of cells immunoreactive to AR and ER alpha, or detected using the Nissl technique, decreased significantly. These results show that perinatal exposure to Pb alters MRB. This event may be related to a decrease in both the concentrations of sex hormones and the number of cells that express their receptors as well as in the neuronal Nissl staining population. This ultimately affects the quality of life of the individual.es_ES
Doihttps://doi.org/10.1111/iep.12521es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4800
Idiomaenes_ES
EditorialWILEYes_ES
RelaciónInternational Journal of Experimental Pathologyes_ES
URL relacionadohttps://doi.org/10.1111/iep.12521es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Experimental Pathology
Palabra claveandrogen receptores_ES
Palabra claveLeades_ES
Palabra clavemale sexual behavioures_ES
Palabra clavemedial amygdalaes_ES
Palabra clavemedial preoptic areaes_ES
Palabra claveoestrogen receptor alphaes_ES
TítuloPerinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the braines_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorArteaga-Silva, Marcela
AutorVigueras-Villasenor, Rosa Maria
AutorGuillen-Herrera, Gustavo
AutorLandero-Huerta, Daniel Adrian
AutorContreras-Garcia, Itzel Jatziri
AutorMontes, Sergio
AutorRios, Camilo
AutorLimon-Morales, Ofelia
AutorRojas-Castaneda, Julio Cesar
AutorArteaga-Silva, Marcelaes_ES
AutorVigueras-Villasenor, Rosa Mariaes_ES
AutorGuillen-Herrera, Gustavoes_ES
AutorLandero-Huerta, Daniel Adrianes_ES
AutorContreras-Garcia, Itzel Jatziries_ES
AutorMontes, Sergioes_ES
AutorRios, Camiloes_ES
AutorLimon-Morales, Ofeliaes_ES
AutorRojas-Castaneda, Julio Cesares_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1111/iep.12521
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen106es_ES

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