MDR1 C3435T polymorphism in Mexican patients with breast cancer

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:48Z
Fecha de publicación2014-01-01
ResumenWe investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Medico de Occidente (Mexico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52\% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC and HG samples {[}odds ratio (OR) = 0.64, 95\% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24\% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95\%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico.es_ES
Doihttps://doi.org/10.4238/2014.july.4.17es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4605
Idiomaenes_ES
EditorialFUNPEC-EDITORAes_ES
RelaciónGenetics and Molecular Researches_ES
URL relacionadohttps://doi.org/10.4238/2014.july.4.17es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteGenetics and Molecular Research
Palabra claveBreast Canceres_ES
Palabra claveMalignant breast lesionses_ES
Palabra claveFibrocystic changeses_ES
Palabra claveP-glycoproteines_ES
Palabra claveMDR1es_ES
TítuloMDR1 C3435T polymorphism in Mexican patients with breast canceres_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMacias-Gomez, N. M.
AutorGutierrez-Angulo, M.
AutorLeal-Ugarte, E.
AutorRamirez-Reyes, L.
AutorPeregrina-Sandoval, J.
AutorMeza-Espinoza, J. P.
AutorSolano, F. Ramos
Autorde la Luz Ayala-Madrigal, M.
AutorTelles, F. Santoyo
AutorMacias-Gomez, N. M.es_ES
AutorGutierrez-Angulo, M.es_ES
AutorLeal-Ugarte, E.es_ES
AutorRamirez-Reyes, L.es_ES
AutorPeregrina-Sandoval, J.es_ES
AutorMeza-Espinoza, J. P.es_ES
AutorSolano, F. Ramoses_ES
Autorde la Luz Ayala-Madrigal, M.es_ES
AutorTelles, F. Santoyoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas5018-5024es_ES
URL relacionadahttps://doi.org/10.4238/2014.july.4.17
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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