Association of the rs8720 and rs12587 KRAS Gene Variants with Colorectal Cancer in a Mexican Population and Their Analysis In Silico

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:45Z
Fecha de publicación2023-01-01
ResumenColorectal cancer (CRC) is a major global health challenge and one of the top 10 cancers in Mexico. Lifestyle and genetic factors influence CRC development, prognosis, and therapeutic response; identifying risk factors, such as the genes involved, is critical to understanding its behavior, mechanisms, and prognosis. The association between KRAS gene variants (rs8720 and rs12587) and CRC in the Mexican population was analyzed. We performed in silico analysis and analyzed 310 healthy individuals and 385 CRC patients using TaqMan assays and real-time PCR. The CC and GG genotypes of rs8720 and rs12587 were identified as CRC risk factors (p < 0.05). The CC and TC genotypes of the rs8720 were associated with rectal cancer, age over 50 years, moderately differentiated histology, and advanced cancer stage. TG and GG genotypes of the rs12587 variant were a risk factor in the CRC group, in patients with stage I-II, males, and stage III-IV non-chemotherapy response. The TG haplotype is protected against CRC. The combined CCGG genotype was linked to CRC risk. In silico analysis revealed that the rs12587 and rs8720 variants could influence KRAS gene regulation via miRNAs. In conclusion, rs8720 and rs12587 variants of the KRAS gene were associated with CRC risk and could influence KRAS regulation via miRNAs.es_ES
Doihttps://doi.org/10.3390/cells12151941es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4594
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónCellses_ES
URL relacionadohttps://doi.org/10.3390/cells12151941es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCells
Palabra clavecolorectal neoplasmses_ES
Palabra claveKRAS genees_ES
Palabra clavepolymorphismes_ES
Palabra clavesingle nucleotidees_ES
Palabra clavein silico analysises_ES
Palabra clavegenetic variationes_ES
Palabra clavegenetic predisposition to diseasees_ES
Palabra clavemicroRNAses_ES
TítuloAssociation of the rs8720 and rs12587 KRAS Gene Variants with Colorectal Cancer in a Mexican Population and Their Analysis In Silicoes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorPatricia Gallegos-Arreola, Martha
AutorFelipe Garibaldi-Rios, Asbiel
AutorIsrael Cruz-Sanchez, Jose
AutorEduardo Figuera, Luis
AutorAlberto Ronquillo-Carreon, Carlos
AutorAlejandra Rosales-Reynoso, Monica
AutorClaudia Gomez-Meda, Belinda
AutorAlejandro Carrillo-Davila, Irving
AutorMaria Puebla-Perez, Ana
AutorMontoya-Fuentes, Hector
AutorPeralta-Leal, Valeria
AutorZuniga-Gonzalez, Guillermo M.
AutorPatricia Gallegos-Arreola, Marthaes_ES
AutorFelipe Garibaldi-Rios, Asbieles_ES
AutorIsrael Cruz-Sanchez, Josees_ES
AutorEduardo Figuera, Luises_ES
AutorAlberto Ronquillo-Carreon, Carloses_ES
AutorAlejandra Rosales-Reynoso, Monicaes_ES
AutorClaudia Gomez-Meda, Belindaes_ES
AutorAlejandro Carrillo-Davila, Irvinges_ES
AutorMaria Puebla-Perez, Anaes_ES
AutorMontoya-Fuentes, Hectores_ES
AutorPeralta-Leal, Valeriaes_ES
AutorZuniga-Gonzalez, Guillermo M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número15es_ES
URL relacionadahttps://doi.org/10.3390/cells12151941
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen12es_ES

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