Rutin Metabolites as Powerful Inhibitors of Advanced Glycation End Products

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:31:52Z
Fecha de publicación2008-01-01
ResumenGlycation is a non‐enzymatic reaction between reducing sugars and protein‐amino groups that through ketoamines leads to advanced glycation end products (AGEs) such as fluorescent and non‐fluorescent ( N ε ‐carboxymethyllysine, CML) protein adducts. Glycation is implicated in diabetic complications involving kidney, eye and neuron damage. Aminoguanidine (AG), a powerful AGE inhibitor, induced critical side effects when tested as anti‐diabetic drug in clinical trials. This showed a need for new and improved AGE inhibitors. Histone H1 and ADP‐ribose were used as a glycation model since it allows to distinguish true AGE inhibitors from general antioxidants. Rutin derivatives were tested as AGE inhibitors since rutin, a dietary flavonoid contained in plant‐derived products, isn't absorbed intact due to gut microflora degradation. Our data showed that 3,4‐dihydroxyphenylacetic acid and 3,4‐dihydroxytoluene were equal or better inhibitors of fluorescence, and CML‐protein adducts than AG. In contrast, homovanillic acid and 3‐hydroxyphenylacetic acid, weren't as effective AGE inhibitors. Methylglyoxal and glyoxal were used as glycating agents of histone H1 to elucidate the mechanism of AGE‐inhibition and effective AGE inhibition was observed with rutin metabolites and AG. These results present alternative effective AGE inhibitors to AG that might be recommended as supplements in the prevention of diabetes complications.es_ES
Doihttps://doi.org/10.1096/fasebj.22.1_supplement.614.12es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/3609
Idiomaenes_ES
EditorialWileyes_ES
RelaciónThe FASEB Journales_ES
URL relacionadohttps://doi.org/10.1096/fasebj.22.1_supplement.614.12es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteThe FASEB Journal
TítuloRutin Metabolites as Powerful Inhibitors of Advanced Glycation End Productses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLaurean, Daniel Cervantes
AutorPashikanti, Srinath
AutorLaurean, Daniel Cervanteses_ES
AutorPashikanti, Srinathes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
NúmeroS1es_ES
URL relacionadahttps://doi.org/10.1096/fasebj.22.1_supplement.614.12
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen22es_ES

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