Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:42Z
Fecha de publicación2020-01-01
ResumenBackground: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100\% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50-200\% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed.es_ES
Doihttps://doi.org/10.1016/j.waojou.2020.100444es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5503
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónWorld Allergy Organization Journales_ES
URL relacionadohttps://doi.org/10.1016/j.waojou.2020.100444es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteWorld Allergy Organization Journal
Palabra claveAllergen immunotherapyes_ES
Palabra claveGuidelinees_ES
Palabra claveSubcutaneous immunotherapyes_ES
Palabra claveSublingual immunotherapyes_ES
Palabra claveAllergen extractes_ES
TítuloCompromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelineses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLarenas-Linnemann, Desiree
AutorRodriguez-Perez, Noel
AutorLuna-Pech, Jorge A.
AutorRodriguez-Gonzalez, Monica
AutorVirginia Blandon-Vijil, Maria
AutorDel-Rio-Navarro, Blanca E.
Autordel Carmen Costa-Dominguez, Maria
AutorMaureen Navarrete-Rodriguez, Elsy
AutorMacouzet-Sanchez, Carlos
AutorAntonio Ortega-Martell, Jose
AutorFireth Pozo-Beltran, Cesar
AutorEstrada-Cardona, Alan
AutorArias-Cruz, Alfredo
AutorRodriguez Galvan, Karen Guadalupe
AutorBrito-Diaz, Herson
AutorDel Rosario Canseco-Raymundo, Maria
AutorEmanuel Castelan-Chavez, Enrique
AutorJose Escalante-Dominguez, Alberto
AutorLuis Galvez-Romero, Jose
AutorGomez-Vera, Javier
AutorNora Gonzalez-Diaz, Sandra
AutorBelinda Guerrero-Nunez, Maria Gracia
AutorDaniel Hernandez-Colin, Dante
AutorMacias-Weinmann, Alejandra
AutorAlejandro Mendoza-Hernandez, David
AutorAlejandro Meneses-Sanchez, Nestor
AutorDolores Mogica-Martinez, Maria
AutorVivian Moncayo-Coello, Carol
AutorManuel Montiel-Herrera, Juan
AutorMaria O'Farril-Romanillos, Patricia
AutorOnuma-Takane, Ernesto
AutorOrtega-Cisneros, Margarita
AutorRangel-Garza, Lorena
AutorStone-Aguilar, Hector
AutorTorres-Lozano, Carlos
AutorVenegas-Montoya, Edna
AutorWakida-Kusunoki, Guillermo
AutorPartida-Gaytan, Armando
AutorInes Lopez-Garcia, Aida
AutorPaola Macias-Robles, Ana
Autorde Jesus Ambriz-Moreno, Maria
AutorAli Azamar-Jacome, Amyra
AutorYusdivia Beltran-De Paz, Claudia
AutorCaballero-Lopez, Chrystopherson
AutorFernandez De Cordova-Aguirre, Juan Carlos
AutorRoberto Fernandez-Soto, Jose
AutorSantos Lozano-Saenz, Jose
AutorJoel Oyoqui-Flores, Jose
AutorEfrain Osorio-Escamilla, Roberto
AutorRamirez-Jimenez, Fernando
AutorRivero-Yeverino, Daniela
AutorMartinez Infante, Eric
AutorAlejandro Medina-Avalos, Miguel
AutorLarenas-Linnemann, Desireees_ES
AutorRodriguez-Perez, Noeles_ES
AutorLuna-Pech, Jorge A.es_ES
AutorRodriguez-Gonzalez, Monicaes_ES
AutorVirginia Blandon-Vijil, Mariaes_ES
AutorDel-Rio-Navarro, Blanca E.es_ES
Autordel Carmen Costa-Dominguez, Mariaes_ES
AutorMaureen Navarrete-Rodriguez, Elsyes_ES
AutorMacouzet-Sanchez, Carloses_ES
AutorAntonio Ortega-Martell, Josees_ES
AutorFireth Pozo-Beltran, Cesares_ES
AutorEstrada-Cardona, Alanes_ES
AutorArias-Cruz, Alfredoes_ES
AutorRodriguez Galvan, Karen Guadalupees_ES
AutorBrito-Diaz, Hersones_ES
AutorDel Rosario Canseco-Raymundo, Mariaes_ES
AutorEmanuel Castelan-Chavez, Enriquees_ES
AutorJose Escalante-Dominguez, Albertoes_ES
AutorLuis Galvez-Romero, Josees_ES
AutorGomez-Vera, Javieres_ES
AutorNora Gonzalez-Diaz, Sandraes_ES
AutorBelinda Guerrero-Nunez, Maria Graciaes_ES
AutorDaniel Hernandez-Colin, Dantees_ES
AutorMacias-Weinmann, Alejandraes_ES
AutorAlejandro Mendoza-Hernandez, Davides_ES
AutorAlejandro Meneses-Sanchez, Nestores_ES
AutorDolores Mogica-Martinez, Mariaes_ES
AutorVivian Moncayo-Coello, Caroles_ES
AutorManuel Montiel-Herrera, Juanes_ES
AutorMaria O'Farril-Romanillos, Patriciaes_ES
AutorOnuma-Takane, Ernestoes_ES
AutorOrtega-Cisneros, Margaritaes_ES
AutorRangel-Garza, Lorenaes_ES
AutorStone-Aguilar, Hectores_ES
AutorTorres-Lozano, Carloses_ES
AutorVenegas-Montoya, Ednaes_ES
AutorWakida-Kusunoki, Guillermoes_ES
AutorPartida-Gaytan, Armandoes_ES
AutorInes Lopez-Garcia, Aidaes_ES
AutorPaola Macias-Robles, Anaes_ES
Autorde Jesus Ambriz-Moreno, Mariaes_ES
AutorAli Azamar-Jacome, Amyraes_ES
AutorYusdivia Beltran-De Paz, Claudiaes_ES
AutorCaballero-Lopez, Chrystophersones_ES
AutorFernandez De Cordova-Aguirre, Juan Carloses_ES
AutorRoberto Fernandez-Soto, Josees_ES
AutorSantos Lozano-Saenz, Josees_ES
AutorJoel Oyoqui-Flores, Josees_ES
AutorEfrain Osorio-Escamilla, Robertoes_ES
AutorRamirez-Jimenez, Fernandoes_ES
AutorRivero-Yeverino, Danielaes_ES
AutorMartinez Infante, Erices_ES
AutorAlejandro Medina-Avalos, Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
URL relacionadahttps://doi.org/10.1016/j.waojou.2020.100444
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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