Leptin facilitates lordosis behavior through GnRH-1 and progestin receptors in estrogen-primed rats

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:31Z
Fecha de publicación2011-01-01
ResumenDose response curves for leptin facilitation of estrous behavior (lordosis and proceptivity) were made by infusing the peptide into the lateral ventricle (icv) of ovariectomized (ovx), ad libitum-fed rats injected 40 h previously with 5 mu g of estradiol benzoate. Leptin doses of 1 and 3 mu g produced significant lordosis quotient at 60 min post-injection, with maximal lordosis being displayed at 120 min. Yet the intensity of lordosis was weak, and a high incidence of rejection behaviors was found. Moreover, leptin did not induce significant proceptive behaviors at any dose. The leptin doses of 1 and 3 mu g were selected for determining whether antide, a GnRH-1 receptor antagonist, or the progestin receptor antagonist RU486 could modify the lordosis response to leptin. Icv injection of either antide or RU486 1 h before leptin significantly depressed leptin facilitation of lordosis. The results suggest that leptin stimulates lordosis by releasing GnRH, which in turn activates GnRH-1 and progestin receptors. The physiological role of leptin in the control of estrous behavior remains to be determined. (c) 2010 Elsevier Ltd. All rights reserved.es_ES
Doihttps://doi.org/10.1016/j.npep.2010.11.001es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5320
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónNeuropeptideses_ES
URL relacionadohttps://doi.org/10.1016/j.npep.2010.11.001es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteNeuropeptides
Palabra claveLeptines_ES
Palabra claveLordosis behaviores_ES
Palabra claveProceptive behaviores_ES
Palabra claveRejection behaviores_ES
Palabra claveGnRH-1 receptores_ES
Palabra claveProgestin receptores_ES
Palabra claveAntidees_ES
Palabra claveRU486es_ES
TítuloLeptin facilitates lordosis behavior through GnRH-1 and progestin receptors in estrogen-primed ratses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorGarcia-Juarez, Marcos
AutorBeyer, Carlos
AutorSoto-Sanchez, Alfonso
AutorDominguez-Ordonez, Raymundo
AutorGomora-Arrati, Porfirio
AutorJavier Lima-Hernandez, Francisco
AutorEguibar, Jose R.
AutorEtgen, Anne M.
AutorGonzalez-Flores, Oscar
AutorGarcia-Juarez, Marcoses_ES
AutorBeyer, Carloses_ES
AutorSoto-Sanchez, Alfonsoes_ES
AutorDominguez-Ordonez, Raymundoes_ES
AutorGomora-Arrati, Porfirioes_ES
AutorJavier Lima-Hernandez, Franciscoes_ES
AutorEguibar, Jose R.es_ES
AutorEtgen, Anne M.es_ES
AutorGonzalez-Flores, Oscares_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
Rango de páginas63-67es_ES
URL relacionadahttps://doi.org/10.1016/j.npep.2010.11.001
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen45es_ES

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