The neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodeling

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:31Z
Fecha de publicación2020-01-01
ResumenThe adult K/BxN transgenic mouse develops spontaneous autoimmune arthritis with joint remodeling and profound bone loss. We report that both males and females display a severe sustained tactile allodynia which is reduced by gabapentin but not the potent cyclooxygenase inhibitor ketorolac. In dorsal horn, males and females show increased GFAP(+) astrocytic cells; however, only males demonstrate an increase in Iba1(+) microglia. In dorsal root ganglia (DRG), there is an increase in C GRP(+), TH+, and Iba1(+) (macrophage) labeling, but no increase in ATF3(+) cells. At the ankle there is increased CGRP(+), TH+, and GAP-43(+) fiber synovial innervation. Thus, based on the changes in dorsal horn, DRG and peripheral innervation, we suggest that the adult K/BxN transgenic arthritic mice display a neuropathic phenotype, an assertion consistent with the analgesic pharmacology seen in this animal. These results indicate the relevance of this model to our understanding of the nociceptive processing which underlies the chronic pain state that evolves secondary to persistent joint inflammation.es_ES
Doihttps://doi.org/10.1038/s41598-020-72441-5es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5308
Idiomaenes_ES
EditorialNATURE PORTFOLIOes_ES
RelaciónScientific Reportses_ES
URL relacionadohttps://doi.org/10.1038/s41598-020-72441-5es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteScientific Reports
TítuloThe neuropathic phenotype of the K/BxN transgenic mouse with spontaneous arthritis: pain, nerve sprouting and joint remodelinges_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autordos Santos, Gilson Goncalves
AutorJimenez-Andrade, Juan Miguel
AutorWoller, Sarah A.
AutorMunoz-Islas, Enriqueta
AutorBeatriz Ramirez-Rosas, Martha
AutorOhashi, Nobuko
AutorCatroli, Glaucilene Ferreira
AutorFujita, Yuya
AutorYaksh, Tony L.
AutorCorr, Maripat
Autordos Santos, Gilson Goncalveses_ES
AutorJimenez-Andrade, Juan Migueles_ES
AutorWoller, Sarah A.es_ES
AutorMunoz-Islas, Enriquetaes_ES
AutorBeatriz Ramirez-Rosas, Marthaes_ES
AutorOhashi, Nobukoes_ES
AutorCatroli, Glaucilene Ferreiraes_ES
AutorFujita, Yuyaes_ES
AutorYaksh, Tony L.es_ES
AutorCorr, Maripates_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número1es_ES
URL relacionadahttps://doi.org/10.1038/s41598-020-72441-5
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen10es_ES

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