Oral Vaccination With a Formulation Combining Rhipicephalus microplus Subolesin With Heat Inactivated Mycobacterium bovis Reduces Tick Infestations in Cattle

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:32Z
Fecha de publicación2019-01-01
ResumenVaccines are an environmentally friendly alternative to acaracides for the control of tick infestations, to reduce the risk for tick-borne diseases affecting human and animal health worldwide, and to improve animal welfare and production. Subolesin (SUB, also known as 4D8) is the functional homolog of Akirin2 involved in the regulation of development and innate immune response, and a proven protective antigen for the control of ectoparasite infestations and pathogen infection. Oral vaccination combining protein antigens with immunostimulants has proven efficacy with increased host welfare and safety, but has not been used for the control of tick infestations. Here we describe the efficacy of oral vaccination with a formulation combining Rhipicephalus microplus SUB and heat inactivated Mycobacterium bovis (IV) on cattle tick infestations and fertility. The levels of IgG antibody titers against SUB and M. bovis P22, and the expression of selected immune response genes were determined and analyzed as possible correlates of protection. We demonstrated that oral immunization with the SUB+IV formulation resulted in 51\% reduction in the number of female ticks and 30\% reduction in fertility with an overall efficacy of 65\% in the control of R. microplus infestations by considering the cumulative effect on reducing tick survival and fertility in cattle. The akr2, IL-1 beta, and C3 mRNA levels together with antibody levels against SUB correlated with vaccine efficacy. The effect of the oral immunization with SUB+IV in cattle on tick survival and fertility is essential to reduce tick infestations, and extended previous results on the effect of R. microplus SUB for the control of cattle tick infestations. These results support the development of oral vaccines formulations for the control of tick infestations and the incidence of tick-borne diseases.es_ES
Doihttps://doi.org/10.3389/fcimb.2019.00045es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5361
Idiomaenes_ES
EditorialFRONTIERS MEDIA SAes_ES
RelaciónFrontiers in Cellular and Infection Microbiologyes_ES
URL relacionadohttps://doi.org/10.3389/fcimb.2019.00045es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteFrontiers in Cellular and Infection Microbiology
Palabra clavesubolesines_ES
Palabra clavecattle tickes_ES
Palabra clavevaccinees_ES
Palabra claveoral vaccinationes_ES
Palabra claveRhipicephalus micropluses_ES
Palabra claveheat inactivated Mycobacterium bovises_ES
TítuloOral Vaccination With a Formulation Combining Rhipicephalus microplus Subolesin With Heat Inactivated Mycobacterium bovis Reduces Tick Infestations in Cattlees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorContreras, Marinela
AutorKasaija, Paul D.
AutorMerino, Octavio
Autorde la Cruz-Hernandez, I, Ned
AutorGortazar, Christian
Autorde la Fuente, Jose
AutorContreras, Marinelaes_ES
AutorKasaija, Paul D.es_ES
AutorMerino, Octavioes_ES
Autorde la Cruz-Hernandez, I, Nedes_ES
AutorGortazar, Christianes_ES
Autorde la Fuente, Josees_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.3389/fcimb.2019.00045
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

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