MDR1 C3435T Polymorphism in Mexican Children with Acute Lymphoblastic Leukemia and in Healthy Individuals

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:38Z
Fecha de publicación2008-08-01
ResumenTo determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. All subjects were genotyped for the C3435T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. The genotype frequencies in the patients were 17% homozygous CC, 61% heterozygous CT, and 22% homozygous TT; in healthy individuals the genotype frequencies were 14% CC, 53% CT, and 33% TT. In patients with ALL the allele frequencies were 0.47 for the C allele and 0.53 for the T allele; in the healthy group these allele frequencies were 0.40 and 0.60 for the C and T alleles, respectively. No significant differences in allele frequency (p > 0.176) and genotype frequency (p > 0.255) were detected between the two groups. These findings suggest that the CT or TT genotype does not increase the risk for childhood ALL in Mexican patients. On the other hand, significant differences in allele frequencies were detected in the comparison of Mexican healthy subjects with other populations. Whether these differences are fortuitous or related to diverse genetic backgrounds remains to be elucidated.es_ES
Doihttps://doi.org/10.3378/1534-6617-80.4.449es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2610
Idiomaenes_ES
EditorialWayne State University Presses_ES
RelaciónHuman Biologyes_ES
URL relacionadohttps://doi.org/10.3378/1534-6617-80.4.449es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteHuman Biology
Palabra claveGenotypees_ES
Palabra claveAllelees_ES
Palabra claveAllele frequencyes_ES
Palabra claveLymphoblastic Leukemiaes_ES
Palabra clavePolymorphism (computer science)es_ES
Palabra claveGenotype frequencyes_ES
Palabra claveBiologyes_ES
Palabra clavePolymerase chain reactiones_ES
Palabra claveGeneticses_ES
Palabra claveRestriction fragment length polymorphismes_ES
Palabra claveGastroenterologyes_ES
Palabra claveLeukemiaes_ES
ClasificaciónAcute Lymphoblastic Leukemia researches_ES
TítuloMDR1 C3435T Polymorphism in Mexican Children with Acute Lymphoblastic Leukemia and in Healthy Individualses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorLeal‐Ugarte, Evelia
AutorGutiérrez‐Angulo, Melva
AutorMacías‐Gómez, Nelly Margarita
AutorPeralta-Leal, Valeria
AutorDurán-González, Jorge
AutorAyala‐Madrigal, María de la Luz
AutorPartida-Pérez, Miriam
AutorBarros‐Núñez, Patricio
AutorRuiz-Díaz, Dinorah
AutorMoreno-Ortíz, José Miguel
AutorPeregrina-Sandoval, Jorge
AutorMeza-Espinoza, Juan Pablo
AutorLeal‐Ugarte, Eveliaes_ES
AutorGutiérrez‐Angulo, Melvaes_ES
AutorMacías‐Gómez, Nelly Margaritaes_ES
AutorPeralta-Leal, Valeriaes_ES
AutorDurán-González, Jorgees_ES
AutorAyala‐Madrigal, María de la Luzes_ES
AutorPartida-Pérez, Miriames_ES
AutorBarros‐Núñez, Patricioes_ES
AutorRuiz-Díaz, Dinorahes_ES
AutorMoreno-Ortíz, José Migueles_ES
AutorPeregrina-Sandoval, Jorgees_ES
AutorMeza-Espinoza, Juan Pabloes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
Rango de páginas449-455es_ES
URL relacionadahttps://doi.org/10.3378/1534-6617-80.4.449
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen80es_ES

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