Genetic Variants and Their Putative Effects on microRNA-Seed Sites: Characterization of the 3′ Untranslated Region of Genes Associated with Temperament
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-10-05T16:33:34Z | |
| Fecha de publicación | 2023-01-01 | |
| Resumen | The 3 ` untranslated region has an important role in gene regulation through microRNAs, and it has been estimated that microRNAs regulate up to 50\% of coding genes in mammals. With the aim of allelic variant identification of 3 ` untranslated region microRNA seed sites, the 3 ` untranslated region was searched for seed sites of four temperament-associated genes (CACNG4, EXOC4, NRXN3, and SLC9A4). The microRNA seed sites were predicted in the four genes, and the CACNG4 gene had the greatest number with 12 predictions. To search for variants affecting the predicted microRNA seed sites, the four 3 ` untranslated regions were re-sequenced in a Brahman cattle population. Eleven single nucleotide polymorphisms were identified in the CACNG4, and eleven in the SLC9A4. Rs522648682:T>G of the CACNG4 gene was located at the predicted seed site for bta-miR-191. Rs522648682:T>G evidenced an association with both exit velocity (p = 0.0054) and temperament score (p = 0.0097). The genotype TT had a lower mean exit velocity (2.93 +/- 0.4 m/s) compared with the TG and GG genotypes (3.91 +/- 0.46 m/s and 3.67 +/- 0.46 m/s, respectively). The allele associated with the temperamental phenotype antagonizes the seed site, disrupting the bta-miR-191 recognition. The G allele of CACNG4-rs522648682 has the potential to influence bovine temperament through a mechanism associated with unspecific recognition of bta-miR-191. | es_ES |
| Doi | https://doi.org/10.3390/genes14051004 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/5401 | |
| Idioma | en | es_ES |
| Editorial | MDPI | es_ES |
| Relación | Genes | es_ES |
| URL relacionado | https://doi.org/10.3390/genes14051004 | es_ES |
| Derechos | Acceso abierto (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_abf2 | es_ES |
| Fuente | Genes | |
| Palabra clave | 3 ` UTR | es_ES |
| Palabra clave | SNP | es_ES |
| Palabra clave | candidate genes | es_ES |
| Palabra clave | cattle behavior | es_ES |
| Palabra clave | temperament | es_ES |
| Palabra clave | microRNA | es_ES |
| Palabra clave | seed site | es_ES |
| Título | Genetic Variants and Their Putative Effects on microRNA-Seed Sites: Characterization of the 3′ Untranslated Region of Genes Associated with Temperament | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | Ruiz-De-La-Cruz, Gilberto | |
| Autor | Sifuentes-Rincon, Ana Maria | |
| Autor | Casas, Eduardo | |
| Autor | Paredes-Sanchez, Francisco Alejandro | |
| Autor | Parra-Bracamonte, Gaspar Manuel | |
| Autor | Riley, David G. | |
| Autor | Perry, George A. | |
| Autor | Welsh, Jr Thomas H. | |
| Autor | Randel, Ronald D. | |
| Autor | Ruiz-De-La-Cruz, Gilberto | es_ES |
| Autor | Sifuentes-Rincon, Ana Maria | es_ES |
| Autor | Casas, Eduardo | es_ES |
| Autor | Paredes-Sanchez, Francisco Alejandro | es_ES |
| Autor | Parra-Bracamonte, Gaspar Manuel | es_ES |
| Autor | Riley, David G. | es_ES |
| Autor | Perry, George A. | es_ES |
| Autor | Welsh, Jr Thomas H. | es_ES |
| Autor | Randel, Ronald D. | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Número | 5 | es_ES |
| URL relacionada | https://doi.org/10.3390/genes14051004 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 14 | es_ES |