Exploring the Combined Effect of Bm86 and Subolesin Polypeptide Vaccines in Cattle Naturally Infested with Rhipicephalus microplus

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:16Z
Fecha de publicación2026-01-01
ResumenRhipicephalus microplus infestations are a major concern for cattle production in neotropical regions. Anti-tick vaccines represent a sustainable alternative to chemical acaricides; however, improving vaccine efficacy remains challenging. This study evaluated the protective efficacy of polypeptide-based formulations of pBm86 and pSubolesin administered as co-immunization or as a cocktail in naturally infested cattle. Twelve calves were assigned to three groups: G1: 100 μg pBm86 + 50 μg pSubolesin co-immunized; G2: same formulation in cocktail; and G3: control. The cocktail significantly reduced adult female tick numbers, oviposition, and larvae hatching (p < 0.05), achieving a vaccine efficacy of 75%. In contrast, co-immunization achieved 50% efficacy. Vaccinated cattle developed significantly increased antigen-specific IgG levels against Subolesin than Bm86. IgG antibodies recognized native tick proteins by Western blot, and their efficacy was confirmed in vitro using blood-feeding assays. These results indicate that the cocktail formulation showed improved efficacy compared with co-immunization in this study, possibly by affecting complementary biological processes in ticks. Finally, this study supports the development of multi-antigen, polypeptide-based vaccines as a promising and sustainable approach for the control of R. microplus under natural field conditions.es_ES
Doihttps://doi.org/10.3390/vetsci13030301es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2225
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónVeterinary Scienceses_ES
URL relacionadohttps://doi.org/10.3390/vetsci13030301es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteVeterinary Sciences
TítuloExploring the Combined Effect of Bm86 and Subolesin Polypeptide Vaccines in Cattle Naturally Infested with Rhipicephalus micropluses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMendoza-Martínez, Nancy
AutorAlonso-Díaz, Miguel Ángel
AutorMerino-Charrez, Jose Octavio
AutorLagunes-Quintanilla, Rodolfo
AutorMendoza-Martínez, Nancyes_ES
AutorAlonso-Díaz, Miguel Ángeles_ES
AutorMerino-Charrez, Jose Octavioes_ES
AutorLagunes-Quintanilla, Rodolfoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número3es_ES
Rango de páginas301es_ES
URL relacionadahttps://doi.org/10.3390/vetsci13030301
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen13es_ES

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