The Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Death

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:12Z
Fecha de publicación2019-01-01
ResumenWe elucidate the relevance of fibroblast growth factor 15 (FGF15) in liver transplantation (LT) using rats with both steatotic and non-steatotic organs from donors after cardiocirculatory death (DCD). Compared to LT from non-DCDs, the induction of cardiocirculatory death (CD) increases hepatic damage, proliferation, and intestinal and circulatory FGF15. This is associated with high levels of FGF15, bilirubin and bile acids (BAs), and overexpression of the enzyme involved in the alternative BA synthesis pathway, CYP27A1, in non-steatotic livers. Furthermore, CD activates the proliferative pathway, Hippo/YAP, in these types of liver. Blocking FGF15 action in LT from DCDs does not affect CYP27A1 but causes an overexpression of CYP7A, an enzyme from the classic BA synthesis pathway, and this is related to further accumulation of BAs and exacerbated damage. FGF15 inhibition also impairs proliferation without changing Hippo/YAP. In spite of worse damage, steatosis prevents a proliferative response in livers from DCDs. In steatotic grafts, CD does not modify CYP7A1, CYP27A1, BA, or the Hippo/YAP pathway, and FGF15 is not involved in damage or proliferation. Thus, endogenous FGF15 protects against BA accumulation and damage and promotes regeneration independently of the Hippo/YAP pathway, in non-steatotic LT from DCDs. Herein we show a minor role of FGF15 in steatotic LT from DCDs.es_ES
Doihttps://doi.org/10.3390/cells8121640es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5019
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónCellses_ES
URL relacionadohttps://doi.org/10.3390/cells8121640es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteCells
Palabra clavecardiocirculatory deathes_ES
Palabra claveFGF15es_ES
Palabra claveliver transplantationes_ES
Palabra clavesteatotic liver graftses_ES
Palabra claveischemia-reperfusion damagees_ES
TítuloThe Effect of Fibroblast Growth Factor 15 Signaling in Non-Steatotic and Steatotic Liver Transplantation from Cardiocirculatory Deathes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorAvalos-de Leon, Cindy G.
AutorJimenez-Castro, Monica B.
AutorCornide-Petronio, Maria Eugenia
AutorGulfo, Jose
AutorRotondo, Floriana
AutorGracia-Sancho, Jordi
AutorCasillas-Ramirez, Arani
AutorPeralta, Carmen
AutorAvalos-de Leon, Cindy G.es_ES
AutorJimenez-Castro, Monica B.es_ES
AutorCornide-Petronio, Maria Eugeniaes_ES
AutorGulfo, Josees_ES
AutorRotondo, Florianaes_ES
AutorGracia-Sancho, Jordies_ES
AutorCasillas-Ramirez, Aranies_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número12es_ES
URL relacionadahttps://doi.org/10.3390/cells8121640
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen8es_ES

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