Early Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmium

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:27Z
Fecha de publicación2025-01-01
ResumenSperm maturation involves changes in plasma membrane glycosylation for fertilization. Cadmium (Cd) exerts a negative effect by disrupting testicular and epididymal function, altering antioxidant activity. Zinc (Zn) is an essential element known for its antioxidant properties, role in testosterone synthesis, and support of spermatogenesis. However, its effect on sperm membrane glycosylation, as well as endocrine and antioxidant activity, after exposure to Cd has remained unexplored. This study evaluated the impact of Zn on epididymal sperm glycosylation, endocrine activity, and antioxidant activity in Cd-exposed rats. Four groups of male Wistar rats were analyzed: control, Cd-exposed, Zn-supplemented, and Zn + Cd groups. On postnatal day 90, tissues and blood were collected for Zn and Cd quantification, testosterone levels, antioxidant activity, histological analysis, and sperm quality. The results showed that Cd concentration increased significantly, reduced testosterone levels, modified antioxidant activity, and caused structural damage in the epididymis. The Cd-exposed group showed disrupted glycosylation and distribution patterns and reduced sperm quality. The Zn + Cd group showed lower Cd accumulation, preserved testosterone levels, restored antioxidant activity, and preserved glycosylation patterns and sperm quality. This study highlights the protective role of Zn in mitigating Cd-induced reproductive toxicity, probably through the competitive inhibition of Cd uptake and antioxidant support, thereby preserving fertility.es_ES
Doihttps://doi.org/10.3390/ijms26104589es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5289
Idiomaenes_ES
EditorialMDPIes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms26104589es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
Palabra clavesperm maturationes_ES
Palabra clavecadmiumes_ES
Palabra claveglycosylationes_ES
Palabra clavezinces_ES
Palabra clavespermatogenesises_ES
TítuloEarly Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmiumes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autorde Jesus, Sergio Marin
AutorVigueras-Villasenor, Rosa Maria
AutorCortes-Barberena, Edith
AutorHernandez-Rodriguez, Joel
AutorPerez-Aguirre, Sonia Guadalupe
AutorMontes, Sergio
AutorCarrizales-Yanez, Leticia
AutorArrieta-Cruz, Isabel
AutorArteaga-Silva, Marcela
Autorde Jesus, Sergio Marines_ES
AutorVigueras-Villasenor, Rosa Mariaes_ES
AutorCortes-Barberena, Edithes_ES
AutorHernandez-Rodriguez, Joeles_ES
AutorPerez-Aguirre, Sonia Guadalupees_ES
AutorMontes, Sergioes_ES
AutorCarrizales-Yanez, Leticiaes_ES
AutorArrieta-Cruz, Isabeles_ES
AutorArteaga-Silva, Marcelaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número10es_ES
URL relacionadahttps://doi.org/10.3390/ijms26104589
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen26es_ES

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