Biological compatibility of a polylactic acid composite reinforced with natural chitosan obtained from shrimp waste

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:34:12Z
Fecha de publicación2018-01-01
ResumenThe aim of this work is to evaluate the effect of chitosan content (1, 3 and 5 wt %) dispersed in polylactic acid (PLA) on the structure and properties of composites. Also, the hydrolytic degradation, and the cell viability and adhesion of human MG-63 osteoblasts are analyzed to determine the composites' suitability for use in tissue engineering. For the manufacture of the materials, natural chitosan was extracted chemically from shrimp exoskeleton. The composites were fabricated by extrusion, because it is a low-cost process, it is reproducible, and it does not compromise the biocompatibility of the materials. FT-IR and XRD show that the chitosan does not change the polymer structure, and interactions between the composite components are discarded. In vitro degradation tests show that the composites do not induce significant pH changes in phosphate buffer solution due to their low susceptibility to hydrolytic degradation. The adhesion and morphological characteristics of the osteoblasts are evaluated using confocal microscopy and scanning electron microscopy. The cell viability is determined by the MTT assay. Osteoblasts adhesion is observed on the surface of PLA and composites. A higher amount of chitosan, higher number of cells with osteoblastic morphology, and mineralized nodules are observed on the composite surface. The highest metabolic activity is evidenced at 21 days. The results suggest that the Polylactic acid/chitosan composites are potentially suitable for use as a biomaterial.es_ES
Doihttps://doi.org/10.3390/ma11081465es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5974
Idiomaenes_ES
EditorialMDPI AGes_ES
RelaciónMaterialses_ES
URL relacionadohttps://doi.org/10.3390/ma11081465es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMaterials
Palabra claveBiocompositeses_ES
Palabra claveBiomineralizationes_ES
Palabra claveCellular viabilityes_ES
Palabra claveChitosanes_ES
Palabra claveOsteoblastses_ES
Palabra clavePolylactic acides_ES
TítuloBiological compatibility of a polylactic acid composite reinforced with natural chitosan obtained from shrimp wastees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorTorres-Hernández, Yaret Gabriela
AutorOrtega-Díaz, Gloria Michel
AutorTéllez-Jurado, Lucía
AutorCastrejón-Jiménez, Nayeli Shantal
AutorAltamirano-Torres, Alejandro
AutorGarcía-Pérez, Blanca Estela
AutorBalmori-Ramírez, Heberto
AutorTorres-Hernández, Yaret Gabrielaes_ES
AutorOrtega-Díaz, Gloria Micheles_ES
AutorTéllez-Jurado, Lucíaes_ES
AutorCastrejón-Jiménez, Nayeli Shantales_ES
AutorAltamirano-Torres, Alejandroes_ES
AutorGarcía-Pérez, Blanca Estelaes_ES
AutorBalmori-Ramírez, Hebertoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número8es_ES
URL relacionadahttps://doi.org/10.3390/ma11081465
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen11es_ES

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