In vitro growth inhibition and bactericidal activity of spathulenol against drug-resistant clinical isolates of Mycobacterium tuberculosis

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:00Z
Fecha de publicación2019-01-01
ResumenSpathulenol was isolated from an extract of Azorella compacta Phil., Apiaceae, by various chromatographic method; identification of the chemical structure was confirmed by comparing its spectroscopic data with those reported in the literature. The anti-Mycobacterium tuberculosis activity of spathulenol was evaluated on MDR, pre-XDR, and XDR clinical isolates of M. tuberculosis, as well as on the reference susceptible strain H37Rv and its cytotoxic activity was evaluated on the Vero Cell Line. The anti-M. tuberculosis activity of spathulenol was twice as potent against the MDR, pre-XDR, and XDR clinical isolates (6.25 mu g/ml) than on the susceptible H37Rv strain (12.5 mu g/ml). Additionally, the anti-M. tuberculosis activity shown by spathulenol was established as bactericidal on drug-resistant and susceptible strains of M. tuberculosis. Finally, cytotoxic activity on the Vero cell line (CC50 = 95.7 mu g/ml) indicated that spathulenol is a selective anti-M. tuberculosis compound, with a selective index of 15.31 against drug-resistant clinical isolates of M. tuberculosis. (C) 2019 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.es_ES
Doihttps://doi.org/10.1016/j.bjp.2019.06.001es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4819
Idiomaenes_ES
EditorialSPRINGERNATUREes_ES
RelaciónRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosyes_ES
URL relacionadohttps://doi.org/10.1016/j.bjp.2019.06.001es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy
Palabra claveBactericidal activityes_ES
Palabra claveDrug-Resistantes_ES
Palabra claveMycobacterium tuberculosises_ES
Palabra claveSpathulenoles_ES
Palabra claveMulti-drug-resistantes_ES
Palabra claveExtensively-drug-resistantes_ES
TítuloIn vitro growth inhibition and bactericidal activity of spathulenol against drug-resistant clinical isolates of Mycobacterium tuberculosises_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autorde Jesus Dzul-Beh, Angel
AutorGarcia-Sosa, Karlina
AutorHumberto Uc-Cachon, Andres
AutorBorquez, Jorge
AutorLoyola, Luis A.
AutorBarrios-Garcia, Hugo B.
AutorManuel Pena-Rodriguez, Luis
AutorMaria Molina-Salinas, Gloria
Autorde Jesus Dzul-Beh, Angeles_ES
AutorGarcia-Sosa, Karlinaes_ES
AutorHumberto Uc-Cachon, Andreses_ES
AutorBorquez, Jorgees_ES
AutorLoyola, Luis A.es_ES
AutorBarrios-Garcia, Hugo B.es_ES
AutorManuel Pena-Rodriguez, Luises_ES
AutorMaria Molina-Salinas, Gloriaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número6es_ES
Rango de páginas798-800es_ES
URL relacionadahttps://doi.org/10.1016/j.bjp.2019.06.001
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen29es_ES

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