THEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS .21. ONCOGENES INTERPRETED AS EMBRYONIC GENES

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:20Z
Fecha de publicación1988-01-01
ResumenIf oncogenes are interpreted as embryonic genes then the mechanisms for induction of these embryonic genes can be generalized and theoretical considerations can be derived as follows. Agents that induce activity by derepressing embryonic genes can be placed into major groups: (i) translocation inducers, (ii) non-mutating carcinogenic agents, (iii) intercalating DNA groove distorters, and (iv) mutating agents. Translocation inducers work via long terminal repeat insertions, antibody promoter region associations, or V-type position effects. Non-mutational agents such as ethionine cause hyporibosylation of nucleosome core histones or hypomethylation of promoter regions of conformation inducer proteins. All of these agents cause deheterochromatizations of facultative heterochromatin. These processes (or by a classical mutation with mutating agents), cause DNA replication to acquire a new abnormal methylation pattern that is held constant by maintenance DNA methylases. The resultant active series of represssed reduntant type embryonic genes, such as subsets of rDNA genes and tRNA methylase genes, including oncogenes, e.g., protein phosphokinases among other required genes, and spurious irrelevant embryonic genes to the process of carcinogenesis. From the above theory is derived the concept that normal sets of redundant genes, e.g., rDNA are normally activated by planar intercalating agents (steroids) that would simply be the limiting subset of the mechanism used to create an anomalous state when extended to the set of embryonically repressed genes that become activated.es_ES
Doihttps://doi.org/10.1016/0306-9877(88)90153-3es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4186
Idiomaenes_ES
EditorialELSEVIERes_ES
RelaciónMedical Hypotheseses_ES
URL relacionadohttps://doi.org/10.1016/0306-9877(88)90153-3es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteMedical Hypotheses
TítuloTHEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS .21. ONCOGENES INTERPRETED AS EMBRYONIC GENESes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorHANCOCK, RL
AutorHANCOCK, RLes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas93-97es_ES
URL relacionadahttps://doi.org/10.1016/0306-9877(88)90153-3
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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