Experimental Gestational Diabetes Mellitus Prolongs Post-Incisional Mechanical Hypersensitivity and Increases Cutaneous Neuro-Immune Markers in Adult Female Offspring

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:05Z
Fecha de publicación2026-01-01
ResumenPurpose: Gestational diabetes mellitus (GDM) can lead to health complications in adult offspring. It was recently reported that experimental GDM increases intraepidermal nerve fiber density (INFD) in adult mouse offspring. However, the impact of GDM on acute postsurgical pain and the neuroimmune response to incision has not been examined.<br /> Methods: GDM was induced through intraperitoneal administrations of streptozotocin (STZ) in ICR pregnant mouse dams. At 12 weeks old, all female mouse offspring underwent an incision in the glabrous skin of the right hindpaw. The mechanical sensitivity of both incised and non-incised hindpaws was assessed before and during the 3 weeks following the incision. At 16 weeks old, offspring born from dams with and without STZ-induced GDM were euthanized and processed for immunohistochemistry. The INFD (CGRP(+) and PGP9.5(+) axons) and the density of CD68(+) macrophages around the wounded skin were quantified.<br /> Results: Offspring mice of dams with STZ-induced GDM exhibited decreased body weight, yet their blood glucose levels were comparable to those of offspring born from vehicle-treated dams. These offspring of dams with STZ-induced GDM experienced significantly prolonged incision-induced mechanical hypersensitivity compared to offspring of control dams. At 3 weeks post-incision, offspring of STZ-treated dams had an increased density of macrophages and greater INFD of CGRP(+) and PGP9.5(+) axons compared to the values of offspring of vehicle-treated dams.<br /> Conclusion: Offspring of dams with STZ-induced GDM exhibited a delayed resolution of post-incisional pain that was accompanied by increased epidermal nerve fiber density and peri-incisional macrophage activation.es_ES
Doihttps://doi.org/10.2147/jpr.s5948972026es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/3960
Idiomaenes_ES
EditorialDOVE MEDICAL PRESS LTDes_ES
RelaciónJournal of Pain Researches_ES
URL relacionadohttps://doi.org/10.2147/jpr.s5948972026es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteJournal of Pain Research
Palabra clavegestational diabetes mellituses_ES
Palabra clavepost-incisionales_ES
Palabra claverecoveryes_ES
Palabra clavepaines_ES
TítuloExperimental Gestational Diabetes Mellitus Prolongs Post-Incisional Mechanical Hypersensitivity and Increases Cutaneous Neuro-Immune Markers in Adult Female Offspringes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCantu-Cepeda, Carlos A.
AutorVillarreal-Salcido, Jaira
AutorElizondo-Martinez, Cecilia Esther
AutorVazquez-Mora, Juan Antonio
AutorMartinez-Martinez, Arisai
AutorAcosta-Gonzalez, Rosa Issel
AutorJimenez-Andrade, Juan Miguel
AutorMunoz-Islas, Enriqueta
AutorCantu-Cepeda, Carlos A.es_ES
AutorVillarreal-Salcido, Jairaes_ES
AutorElizondo-Martinez, Cecilia Estheres_ES
AutorVazquez-Mora, Juan Antonioes_ES
AutorMartinez-Martinez, Arisaies_ES
AutorAcosta-Gonzalez, Rosa Isseles_ES
AutorJimenez-Andrade, Juan Migueles_ES
AutorMunoz-Islas, Enriquetaes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.2147/jpr.s5948972026
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen19es_ES

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