A Possible Recently Identified Evolutionary Strategy Using Membrane-Bound Vesicle Transfer of Genetic Material to Induce Bacterial Resistance, Virulence and Pathogenicity in Klebsiella oxytoca

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:26Z
Fecha de publicación2026-01-01
ResumenKlebsiella oxytoca has emerged as an important opportunistic pathogen in nosocomial infections, particularly during the COVID-19 pandemic, due to its capacity to acquire and disseminate resistance and virulence genes through horizontal gene transfer (HGT). This study presents a genome-based comparative analysis of K. oxytoca within the genus Klebsiella, aimed at exploring the evolutionary plausibility of outer membrane vesicle (OMV) associated processes in bacterial adaptation. Using publicly available reference genomes, we analyzed pangenome structure, phylogenetic relationships, and the distribution of mobile genetic elements, resistance determinants, virulence factors, and genes related to OMV biogenesis. Our results reveal a conserved set of envelope associated and stress responsive genes involved in vesiculogenic pathways, together with an extensive mobilome and resistome characteristic of the genus. Although these genomic features are consistent with conditions that may favor OMV production, they do not constitute direct evidence of functional OMV mediated horizontal gene transfer. Instead, our findings support a hypothesis generating evolutionary framework in which OMVs may act as a complementary mechanism to established gene transfer routes, including conjugation, integrative mobile elements, and bacteriophages. Overall, this study provides a genomic framework for future experimental and metagenomic investigations into the role of OMV-associated processes in antimicrobial resistance dissemination and should be interpreted as a recently identified evolutionary strategy inferred from genomic data, rather than a novel or experimentally validated mechanism.es_ES
Doihttps://doi.org/10.3390/ijms27020988es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2393
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónInternational Journal of Molecular Scienceses_ES
URL relacionadohttps://doi.org/10.3390/ijms27020988es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteInternational Journal of Molecular Sciences
TítuloA Possible Recently Identified Evolutionary Strategy Using Membrane-Bound Vesicle Transfer of Genetic Material to Induce Bacterial Resistance, Virulence and Pathogenicity in Klebsiella oxytocaes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorTamayo-Ordóñez, Yahaira de Jesús
AutorRosas-García, Ninfa María
AutorBello-López, Juan Manuel
AutorTamayo-Ordóñez, María Concepción
AutorTamayo-Ordóñez, Francisco Alberto
AutorCalzada-Mendoza, Claudia Camelia
AutorAyil-Gutiérrez, Benjamín Abraham
AutorTamayo-Ordóñez, Yahaira de Jesúses_ES
AutorRosas-García, Ninfa Maríaes_ES
AutorBello-López, Juan Manueles_ES
AutorTamayo-Ordóñez, María Concepciónes_ES
AutorTamayo-Ordóñez, Francisco Albertoes_ES
AutorCalzada-Mendoza, Claudia Cameliaes_ES
AutorAyil-Gutiérrez, Benjamín Abrahames_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número2es_ES
Rango de páginas988es_ES
URL relacionadahttps://doi.org/10.3390/ijms27020988
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen27es_ES

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