Phytochemical Analysis and Appraisal of Antiproliferative Activity of Magnolia alejandrae

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:09Z
Fecha de publicación2025-01-01
ResumenBackground: Magnolia alejandrae is a tree endemic to Tamaulipas, Mexico, distributed in the forests of the Sierra Madre Oriental. Objective: Our objective was to analyze the secondary metabolite profile of different parts of M. alejandrae and evaluate their antiproliferative activity in vitro. Methods: Different extracts of leaf, bark, and fruit were obtained using conventional and unconventional extraction methods with solvents of different polarity. The extracts were analyzed by Ultra-Performance Liquid Chromatography-Mass Spectra (UPLC-MS), and their antiproliferative activity against cancer cell lines was determined. Results: The primary yields of the extracts obtained from M. alejandrae ranged from 8.32% to 36.19%. Three hundred and twelve secondary metabolites previously reported from the Magnolia genus were detected. The most frequent were magnone A, pinoresinol, and yangambin. Honokiol and magnolol were not detected. Two of the extracts (FSW and BSW) had antiproliferative activity (IC50 < 140 µg/mL) against HeLa, MCF-7, A549, U373, and PC3 cancer cell lines. The higher activity was against the A549 cell line. Conclusions: M. alejandre extracts showed secondary metabolites previously reported and unreported in other species. Interestingly, some extracts had antiproliferative activity against cancer cell lines. Therefore, M. alejandrae is a source of molecules that could be explored to develop new drugs.es_ES
Doihttps://doi.org/10.3390/metabo15090567es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2108
Idiomaeses_ES
EditorialMDPI AGes_ES
RelaciónMetaboliteses_ES
URL relacionadohttps://doi.org/10.3390/metabo15090567es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteMetabolites
TítuloPhytochemical Analysis and Appraisal of Antiproliferative Activity of Magnolia alejandraees_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorCaballero-Chávez, José E.
AutorPaz-González, Alma D.
AutorNavarrete-Carriola, Diana V.
AutorOlazarán-Santibañez, Fabián E.
AutorEstevez-Carmona, María Miriam
AutorNogueda-Torres, Benjamín
AutorJiménez-Mondragón, Fernando Emiliano
AutorMárquez-Aguilar, Melany X.
AutorPineda-Alcala, Carmen Michelle
AutorCisneros-Juárez, Diego
AutorMarín-Hernández, Álvaro
AutorBandyopadhyay, Debasish
AutorRivera, Gildardo
AutorCaballero-Chávez, José E.es_ES
AutorPaz-González, Alma D.es_ES
AutorNavarrete-Carriola, Diana V.es_ES
AutorOlazarán-Santibañez, Fabián E.es_ES
AutorEstevez-Carmona, María Miriames_ES
AutorNogueda-Torres, Benjamínes_ES
AutorJiménez-Mondragón, Fernando Emilianoes_ES
AutorMárquez-Aguilar, Melany X.es_ES
AutorPineda-Alcala, Carmen Michellees_ES
AutorCisneros-Juárez, Diegoes_ES
AutorMarín-Hernández, Álvaroes_ES
AutorBandyopadhyay, Debasishes_ES
AutorRivera, Gildardoes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número9es_ES
Rango de páginas567es_ES
URL relacionadahttps://doi.org/10.3390/metabo15090567
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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