EGF-GH Axis in Rat Steatotic and Non-steatotic Liver Transplantation From Brain-dead Donors

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-09-15T00:30:58Z
Fecha de publicación2019-07-01
ResumenBACKGROUND: We evaluated the potential dysfunction caused by changes in growth hormone (GH) levels after brain death (BD), and the effects of modulating GH through exogenous epidermal growth factor (EGF) in steatotic and nonsteatotic grafts. METHODS: Steatotic and nonsteatotic grafts from non-BD and BD rat donors were cold stored for 6 hours and transplanted to live rats. Administration of GH and EGF and their underlying mechanisms were characterized in recipients of steatotic and nonsteatotic grafts from BD donors maintained normotensive during the 6 hours before donation. Circulating and hepatic GH and EGF levels, hepatic damage, and regeneration parameters were evaluated. Recipient survival was monitored for 14 days. Somatostatin, ghrelin, and GH-releasing hormones that regulate GH secretion from the anterior pituitary were determined. The survival signaling pathway phosphoinositide-3-kinase/protein kinase B that regulates inflammation (suppressors of cytokine signaling, high-mobility group protein B1, oxidative stress, and neutrophil accumulation) was evaluated. RESULTS: BD reduced circulating GH and increased GH levels only in steatotic livers. GH administration exacerbated adverse BD-associated effects in both types of graft. Exogenous EGF reduced GH in steatotic livers, thus activating cell proliferation and survival signaling pathways, ultimately reducing injury and inflammation. However, EGF increased GH in nonsteatotic grafts, which exacerbated damage. The benefits of EGF for steatotic grafts were associated with increased levels of somatostatin, a GH inhibitor, whereas the deleterious effect on nonsteatotic grafts was exerted through increased amounts of ghrelin, a GH stimulator. CONCLUSIONS: GH treatment is not appropriate in rat liver transplant from BD donors, whereas EGF (throughout GH inhibition) protects only in steatotic grafts.es_ES
Doihttps://doi.org/10.1097/tp.0000000000002636es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/2701
Idiomaenes_ES
EditorialWolters Kluweres_ES
RelaciónTransplantationes_ES
URL relacionadohttps://doi.org/10.1097/tp.0000000000002636es_ES
DerechosAcceso restringido / Suscripción (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_16eces_ES
FuenteTransplantation
Palabra claveEndocrinologyes_ES
Palabra claveInternal medicinees_ES
Palabra claveSomatostatines_ES
Palabra claveGhrelines_ES
Palabra claveEpidermal growth factores_ES
Palabra claveMedicinees_ES
Palabra claveInflammationes_ES
Palabra claveTransplantationes_ES
Palabra claveCytokinees_ES
Palabra claveOxidative stresses_ES
Palabra claveGrowth factores_ES
Palabra claveHormonees_ES
ClasificaciónOrgan Transplantation Techniques and Outcomeses_ES
TítuloEGF-GH Axis in Rat Steatotic and Non-steatotic Liver Transplantation From Brain-dead Donorses_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorÁlvarez‐Mercado, Ana I.
AutorNegrete-Sánchez, Elsa
AutorGulfo, José
AutorLeón, Cindy G. Avalos-de
AutorCasillas-Ramírez, Araní
AutorCornide‐Petronio, María Eugenia
AutorBujaldon, Esther
AutorRotondo, Floriana
AutorGracia‐Sancho, Jordi
AutorJiménez‐Castro, Mónica B.
AutorPeralta, Carmen
AutorÁlvarez‐Mercado, Ana I.es_ES
AutorNegrete-Sánchez, Elsaes_ES
AutorGulfo, Josées_ES
AutorLeón, Cindy G. Avalos-dees_ES
AutorCasillas-Ramírez, Araníes_ES
AutorCornide‐Petronio, María Eugeniaes_ES
AutorBujaldon, Estheres_ES
AutorRotondo, Florianaes_ES
AutorGracia‐Sancho, Jordies_ES
AutorJiménez‐Castro, Mónica B.es_ES
AutorPeralta, Carmenes_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número7es_ES
Rango de páginas1349-1359es_ES
URL relacionadahttps://doi.org/10.1097/tp.0000000000002636
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen103es_ES

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