Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:32:32Z
Fecha de publicación2024-01-01
ResumenBACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood, adolescence, and adulthood; however, the mechanisms by which gestational diabetes mellitus (GDM) predisposes offspring to metabolic disorders remain unknown. AIM To quantify the nerve axons, macrophages, and vasculature in the pancreas from adult offspring born from mouse dams with GDM. METHODS GDM was induced by i.p. administration of streptozotocin (STZ) in ICR mouse dams. At 12 wk old, fasting blood glucose levels were determined in offspring. At 15 wk old, female offspring born from dams with and without GDM were sacrificed and pancreata were processed for immunohistochemistry. We quantified the density of sensory {[}calcitonin gene-related peptide (CGRP)] and tyrosine hydroxylase (TH) axons, blood vessels (endomucin), and macro-phages (CD68) in the splenic pancreas using confocal microscopy. RESULTS Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated dams. However, the density of CGRP+ and TH+ axons, endomucin+ blood vessels, and CD68+ macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control offspring. Likewise, the microvasculature in the islets was significantly greater, but not the number of macrophages within the islets of offspring born from dams with GDM compared to control mice. CONCLUSION GDM induces neuronal, vascular, and inflammatory changes in the pancreas of adult progeny, which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.es_ES
Doihttps://doi.org/10.4239/wjd.v15.i4.758es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/4368
Idiomaenes_ES
EditorialBAISHIDENG PUBLISHING GROUP INCes_ES
RelaciónWorld Journal of Diabeteses_ES
URL relacionadohttps://doi.org/10.4239/wjd.v15.i4.758es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteWorld Journal of Diabetes
Palabra claveGestational diabetes mellituses_ES
Palabra claveImmunohistochemistryes_ES
Palabra claveConfocal microscopyes_ES
Palabra clavePancreases_ES
Palabra claveOffspringes_ES
TítuloLong-term effects of gestational diabetes mellitus on the pancreas of female mouse offspringes_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
AutorMunoz-Islas, Enriqueta
AutorSantiago-SanMartin, Edgar David
AutorMendoza-Sanchez, Eduardo
AutorTorres-Rodriguez, Hector Fabian
AutorRamirez-Quintanilla, Laura Yanneth
AutorPeters, Christopher Michael
AutorJimenez-Andrade, Juan Miguel
AutorMunoz-Islas, Enriquetaes_ES
AutorSantiago-SanMartin, Edgar Davides_ES
AutorMendoza-Sanchez, Eduardoes_ES
AutorTorres-Rodriguez, Hector Fabianes_ES
AutorRamirez-Quintanilla, Laura Yannethes_ES
AutorPeters, Christopher Michaeles_ES
AutorJimenez-Andrade, Juan Migueles_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
Número4es_ES
URL relacionadahttps://doi.org/10.4239/wjd.v15.i4.758
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen15es_ES

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