THEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS .13. MUTATIONAL AND NON-MUTATIONAL MECHANISMS AS SUBSETS OF A MORE GENERAL MECHANISM .B. HEREDITARY TYROSINEMIA
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-10-05T16:32:18Z | |
| Fecha de publicación | 1985-01-01 | |
| Resumen | In this mini-series, 3 different examples of the etiology for the induction of .alpha.-fetoprotein and hepatocarcinogenesis were chosen. In this paper, the mechanism is derived by virtue of a mutation that causes a deficiency in fumarylacetoacetate fumarylhydrolase activity, with subsequent accumulation of fumarylacetoacetate, an inhibitor of ATP:L-methionine-S-adenosyltransferase. It is hypothesized that the chronically low levels of active methyl groups disallow base-pairing by the adenine moiety of S-adenosyl-L-methionine and the repressed conformation of the .alpha.-fetoprotein gene is altered and subsequent transcription takes place. The same or similar process occurs with the subset of genes (embryonically repressed) that, as a special group of active genes, gives embryonic features to a quasi-differentiated stem cell causing ``dysdifferentiation{''} to a neoplastic state. | es_ES |
| Doi | https://doi.org/10.1016/0306-9877(85)90075-1 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/4140 | |
| Idioma | en | es_ES |
| Editorial | ELSEVIER | es_ES |
| Relación | Medical Hypotheses | es_ES |
| URL relacionado | https://doi.org/10.1016/0306-9877(85)90075-1 | es_ES |
| Derechos | Acceso restringido / Suscripción (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_16ec | es_ES |
| Fuente | Medical Hypotheses | |
| Título | THEORETICAL MECHANISMS FOR SYNTHESIS OF CARCINOGEN-INDUCED EMBRYONIC PROTEINS .13. MUTATIONAL AND NON-MUTATIONAL MECHANISMS AS SUBSETS OF A MORE GENERAL MECHANISM .B. HEREDITARY TYROSINEMIA | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | HANCOCK, RL | |
| Autor | HANCOCK, RL | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Número | 2 | es_ES |
| Rango de páginas | 183-187 | es_ES |
| URL relacionada | https://doi.org/10.1016/0306-9877(85)90075-1 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 16 | es_ES |