Memantine protects cholinergic and glutamatergic septal neurons from Aβ1-40-induced toxicity
| Audiencia | Público en general | es_ES |
| Cobertura | México | es_ES |
| Fecha de ingreso | 2026-10-05T16:32:44Z | |
| Fecha de publicación | 2013-01-01 | |
| Resumen | The medial septal region (medial septum and diagonal band of Broca, MS/DB) controls hippocampal excitability and synaptic plasticity. MS/DB cholinergic neurons degenerate early in Alzheimer's disease (AD). The presence of MS/DB glutamatergic neurons that project to the hippocampus and are vulnerable to A beta suggests that excitotoxicity plays a role in AD septal degeneration and hippocampal dysfunction. To demonstrate the presence of excitotoxicity in A beta-induced septal damage, we compared rats injected with A beta(1-40) into the MS/DB with animals treated with memantine prior, during and after A beta(1-40) injections. Controls were injected with phosphate buffered saline (PBS). MS/DB cholinergic, glutamatergic and GABAergic neurons were immunochemically identified. The number of MS/DB neurons was estimated using stereology. Our results show that memantine blocks A beta(1-40)-induced septal damage and suggest that excitotoxicity plays a role in basal forebrain neurodegeneration. Published by Elsevier Ireland Ltd. | es_ES |
| Doi | https://doi.org/10.1016/j.neulet.2013.02.010 | es_ES |
| URI | https://riuat.uat.edu.mx/handle/123456789/4587 | |
| Idioma | en | es_ES |
| Editorial | ELSEVIER IRELAND LTD | es_ES |
| Relación | Neuroscience Letters | es_ES |
| URL relacionado | https://doi.org/10.1016/j.neulet.2013.02.010 | es_ES |
| Derechos | Acceso abierto (Metadatos de producción científica) | es_ES |
| Licencia | http://purl.org/coar/access_right/c_abf2 | es_ES |
| Fuente | Neuroscience Letters | |
| Palabra clave | Septum | es_ES |
| Palabra clave | Excitotoxicity | es_ES |
| Palabra clave | Alzheimer's disease | es_ES |
| Palabra clave | Acetylcholine | es_ES |
| Palabra clave | Glutamate | es_ES |
| Palabra clave | GABA | es_ES |
| Título | Memantine protects cholinergic and glutamatergic septal neurons from Aβ1-40-induced toxicity | es_ES |
| Tipo | Artículo | es_ES |
| Arbitrado | Ha sido Arbitrado | es_ES |
| Autor | Colom, L. V. | |
| Autor | Castaneda, M. T. | |
| Autor | Aleman, D. | |
| Autor | Touhami, A. | |
| Autor | Colom, L. V. | es_ES |
| Autor | Castaneda, M. T. | es_ES |
| Autor | Aleman, D. | es_ES |
| Autor | Touhami, A. | es_ES |
| Institución | Universidad Autónoma de Tamaulipas | |
| Institución | Universidad Autónoma de Tamaulipas | es_ES |
| Rango de páginas | 54-57 | es_ES |
| URL relacionada | https://doi.org/10.1016/j.neulet.2013.02.010 | |
| Tipo de artículo | Indexado | |
| Tipo de artículo | Indexado | es_ES |
| Volumen | 541 | es_ES |