Evidence of the role of tick subolesin in gene expression

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AudienciaPúblico en generales_ES
CoberturaMéxicoes_ES
Fecha de ingreso2026-10-05T16:33:40Z
Fecha de publicación2008-01-01
ResumenBackground: Subolesin is an evolutionary conserved protein that was discovered recently in Ixodes scapularis as a tick protective antigen and has a role in tick blood digestion, reproduction and development. In other organisms, subolesin orthologs may be involved in the control of developmental processes. Because of the profound effect of subolesin knockdown in ticks and other organisms, we hypothesized that subolesin plays a role in gene expression, and therefore affects multiple cellular processes. The objective of this study was to provide evidence for the role of subolesin in gene expression. Results: Two subolesin-interacting proteins were identified and characterized by yeast two-hybrid screen, co-affinity purification and RNA interference (RNAi). The effect of subolesin knockdown on the tick gene expression pattern was characterized by microarray analysis and demonstrated that subolesin RNAi affects the expression of genes involved in multiple cellular pathways. The analysis of subolesin and interacting protein sequences identified regulatory motifs and predicted the presence of conserved protein kinase C (PKC) phosphorylation sites. Conclusion: Collectively, these results provide evidence that subolesin plays a role in gene expression in ticks.es_ES
Doihttps://doi.org/10.1186/1471-2164-9-372es_ES
URIhttps://riuat.uat.edu.mx/handle/123456789/5474
Idiomaenes_ES
EditorialBMCes_ES
RelaciónBMC Genomicses_ES
URL relacionadohttps://doi.org/10.1186/1471-2164-9-372es_ES
DerechosAcceso abierto (Metadatos de producción científica)es_ES
Licenciahttp://purl.org/coar/access_right/c_abf2es_ES
FuenteBMC Genomics
TítuloEvidence of the role of tick subolesin in gene expressiones_ES
TipoArtículoes_ES
ArbitradoHa sido Arbitradoes_ES
Autorde la Fuente, Jose
AutorMaritz-Olivier, Christine
AutorNaranjo, Victoria
AutorAyoubi, Patricia
AutorNijhof, Ard M.
AutorAlmazan, Consuelo
AutorCanales, Mario
AutorPerez de la Lastra, Jose M.
AutorGalindo, Ruth C.
AutorBlouin, Edmour F.
AutorGortazar, Christian
AutorJongejan, Frans
AutorKocan, Katherine M.
Autorde la Fuente, Josees_ES
AutorMaritz-Olivier, Christinees_ES
AutorNaranjo, Victoriaes_ES
AutorAyoubi, Patriciaes_ES
AutorNijhof, Ard M.es_ES
AutorAlmazan, Consueloes_ES
AutorCanales, Marioes_ES
AutorPerez de la Lastra, Jose M.es_ES
AutorGalindo, Ruth C.es_ES
AutorBlouin, Edmour F.es_ES
AutorGortazar, Christianes_ES
AutorJongejan, Franses_ES
AutorKocan, Katherine M.es_ES
InstituciónUniversidad Autónoma de Tamaulipas
InstituciónUniversidad Autónoma de Tamaulipases_ES
URL relacionadahttps://doi.org/10.1186/1471-2164-9-372
Tipo de artículoIndexado
Tipo de artículoIndexadoes_ES
Volumen9es_ES

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